Repositório RCAAP

In Brazil there are nine native species of Aloysia which are poorly studied as the chemical compositions and biological activities. Hence, this study describes the chemical composition determinated by GC-MS of essential oil of the five native and one cultivated species of Aloysia occurring in Rio Grande do Sul and evaluates the cytotoxic effects of the essential oils from A. citrodora, A. lycioides and A. dusenii through the bioassay with Artemia salina. A group of species showed 1,8-cineol as a major compound: A. dusenii (16.2 %), A. citrodora (32.8 %), A. lycioides collected in Guaiba (49.5 %) and A. lycioides collected in São Marcos (17.6 %). While species A. polygalifolia and A. virgata had higher proportions of germacrene-D (11.2 % and 12 %, respectively) and A. chamaedryfolia presented spathulenol (15.6 %). The species A. lycioides collected in Rosário do Sul had β-Phellandrene (23.7 %) as the major compound. All the essential oils tested presented a high toxicity against Artemia salina with LC50 values ​​among 48.12 µg mL-1 and 55.96 µg mL-1.

Providing a quick healing of soft tissue and hard tissue became the greatest goal of surgeons in general, this search started the studies of autologous bioactive surgical additives such as: adhesive fibrin, platelet concentrate rich in plasma and fibrin. Platelet-rich fibrin-PRF was produced in France and is a second-generation platelet concentrate that, due to its properties, provided satisfactory results applied to dentistry, allowing for excellent healing and repair of surgical lesions, aiding in tissue regeneration. It is a 100% autologous safe biomaterial, quick to acquire, more economical, without contraindication, product of the centrifugation of the patient's natural venous blood. Today, much research has been done reporting the use of PRF as a clot and PRF membranes. It is generally applied in oral surgeries for bone augmentation, maxillary sinus elevation, in periodontics, acting in the correction of intraosseous defects and gingival recession, it can also be used for regeneration in open apex, regenerative pulpotomies and periapical surgeries. The present work is a qualitative literature review that aims to carry out a study planning to deepen the knowledge about the application of PRF-Fibrina Rica in platelets. The searches were carried out through selective research of articles, monographs and theses found in electronic databases such as: Pubmed, Scielo and Academic Google with the objective of describing the growth factors present in the PRF, detailing the applicability of the PRF in procedures dental clinics and report the benefits and advantages of PRF over PRP.

Introduction: Obesity and depression are clinical entities whose etiology is a combination of genetic, biological, environmental and psychological factors capable of compromising quality of life. Objective: To evaluate the prevalence of depression before and after bariatric surgery and identify the sociodemographic and clinical characteristics. Methodology: cross-sectional, retrospective, survey-type study conducted in the period 2020-2021. The sample was composed of 5,160 individuals from various regions of Brazil who had undergone bariatric surgery. An online Google Forms questionnaire was used. Results: Of the 5,160 participants, 3199 (62%) did not have and did not develop depression after surgery; 305 (5.9%) had depression and remained after the intervention; 1192 (23.1%) had depression and improved post-surgery and 464 (9%) had no depression developed after surgery. The average age was 37-38 years. It was predominant: female gender, white skin color, complete high school and married individuals. The southeastern region was the most prevalent (p<0.001), as was alcoholism before and after surgery. Physical activity reduced the number of cases of depression after the procedure. Psychological follow-up was performed in 60% of the sample before surgery. The realization time of bariatric surgery was 18-60 months, and the gastric bypass technique was most prevalent. The prevalence of other psychiatric disorders was common among those with a history of depression. Conclusion: Depression was prevalent before and after the surgical intervention, however, bariatric surgery allowed the improvement of depressive disorder among those who already presented the pathology before the procedure.

The purpose of this article is to analyze the problem of contractual management and the damage that contractual interference brings to the municipal public administration.  The perfect management of public administration contracts minimizes problems and eventual failures in performance and delivery. This perfection of management essentially involves a firm contract for performance and a delegation of responsibility to other public agents, which means that the chosen one has a particular responsibility, namely the absolute verification of the contract's performance. In order for such issues to be spared, it is admirable that the contractual management takes place in a prudent and responsible manner. It can also be said that probity must govern the entire life cycle of the contract. The article also deals with the responsibility of the public manager, since he has the right to delegate an administrative act, he continues to be bound by the responsibility for that which has been delegated. The manager has the obligation to make a good choice when appointing the contract inspector, in the sense that by delegating unprepared employees, the public manager will be assuming the risks that may arise from a bad choice.  In addition to responsibly appointing the manager, the public agent must offer training so that the management, if any, can be done in an improved manner. Furthermore, the contract manager/fiscal must be aware that, due to his legal attributions, he has the competence to manage and decide, which makes him responsible for that administered object, so he must manage it properly so that the consequences of the Law do not fall upon him.

Objective: This work aimed of to review the implications of anti-TNF-α therapy in COVID-19 patients associated with the genetic polymorphism (TNF-α polymorphisms in the region-308) of this pertinent cytokine  Methodology: Electronic searches were carried out on PUBMED Central, BVS/BIREME, Web of Science and The Cochrane Library with the aid of key-words. Results: Twenty-six articles were collected. Anti-TNF-α therapy was interpreted and evaluated. Conclusions: Although scarce information is available in the current literature, anti- TNF-α therapy seems to be a viable clinical approach for hospitalized COVID-19 patients who do not need oxygen supply. The genetic polymorphisms, although relevant, may be useful for further researched to assess the clinical response in different research groups.

Aim: To establish a protocol for patients medicated with bisphosphonates, through literature review, to avoid osteonecrosis and to provide professional guidance to accomplish the appropriate treatment. Methodology: On line searches were accomplished for the construction of this paper, which included as databases Web of Science, PUBMED Central, BVS/BIREME, Science Direct, The Cochrane Library and also PROSPERO. Results: The following characteristics were observed in the research of this protocol: Drugs with antireabsorption properties, RANK-L Inhibitor, Antiangiogenic agents, Clinical Manifestations, Drug-related risk factors, Local risk factors to be observed, Systemic and demographic risk factors, High risk factors considered. Conclusions: Bisphosphonates may be a helpful therapy for patients with organic consequences related to the therapy applied with them. Appropriate anamnesis and assessment of the systemic conditions for patients using them are mandatory requirements before their prescription.

Introduction: Pain is a frequent and unwanted symptom in cancer patients and may be a reflection of organic disease or antineoplastic treatments instituted. Occasionally, pharmacological therapy may have limitations in alleviating this condition, with the possibility of including non-pharmacological measures, such as complementary and integrative therapies in health. Objective: To evaluate the effectiveness of complementary and integrative therapies made available by the Unified Health System through the National Policy on Integrative and Complementary Practices in the relief of cancer related pain. Methodology: This is a systematic literature review, with studies published between 2016 and 2020, found in the PubMed database through descriptors validated by DeCS and inclusion and exclusion criteria. Results: Nine articles were selected, of which five researched and demonstrated the effectiveness of acupuncture in pain relief and reduction in the use of analgesics. One study listed the reduction of mucositis severity and pain intensity through the use of herbal plantago major L syrup. The article that studied reflexology demonstrated a reduction in pain intensity. Hypnosis and music therapy did not demonstrate effectiveness in relieving cancer pain among selected studies. Conclusion: Acupuncture is the most studied and most effective therapy for cancer pain relief. More technical-scientific support is needed for the inclusion and use of complementary and integrative practices with satisfactory safety and efficacy in cancer related pain relief.

Introduction: Studies with steroidal and non-steroidal anti-inflammatory drugs in animal models have been carried out in order to verify new therapeutic approaches for the treatment of epilepsy to improve the quality of life of patients with this disease that affects about 65 million people worldwide. Objective: to analyze the relevance of these medications in the treatment of seizures. Methodology: this study is a literature review in order to assess the effects of anti-inflammatory drugs in seizures. Results: the results obtained demonstrate that the animals treated with the steroidal and non-steroidal anti-inflammatory drugs studied had a much lower intensity reduction in convulsive crises without progressing to the Racine 4 scale. Conclusion: It is concluded that the studied steroidal and non-steroidal anti-inflammatory drugs have a protective and reductive effect on inflammatory crises induced by pentilenotetrazol, decreasing the inflammatory cytokines in the central nervous system.

Considering the changes that have occurred in the school over the years, caused by the insertion of digital technologies in the educational context, our teachers have increasingly demanded new skills and competences to work with current 21st century learners. Among all the technologies that we can find each day even more present in the school environment, one that has been standing out in the context of education is the use of digital games, especially those produced for educational purposes. However, as digital games show themselves as a new proposal for teachers to work with students, the question arises regarding the offer of a specific teacher training that aims to prepare these teachers not only for use as also for the construction of these new digital educational resources, considering that these are the professionals who know the pedagogical contents and practices, as well as the reality of the school and students. Therefore, this work seeks to present a Systematic Literature Review that sought to investigate the existence of scientific papers, published between January 2015 and April 2021, about the provision of training for educators for the construction of digital educational games. For the construction of the review, we adopted the steps of planning, conducting and reporting presented in the article's methodology. Thus, it is emphasized that the studies found throughout the review were carefully analyzed and the results found were synthesized throughout this work.

Hospital Dentistry has been gaining field, since several successful experiences, associated with scientific evidence have shown that dental care at the hospital level can contribute to the reduction of cases of nosocomial pneumonia associated with mechanical ventilation, thus reducing the length of hospital stay and consequently the costs of this process. The objective of this study was to verify the efficacy of oral hygiene protocols in ICU patients in the prevention of ventilator-associated pneumonia or nosocomial pneumonia. An integrative literature review was carried out with searches in the Pubmed/MEDLINE and Scielo databases, in which 23 articles were selected for qualitative analysis after application of the eligibility criteria guided by the PRISMA strategy. We noticed that the use of chlorhexidine seems to be the most recurrent protocol in the studies, with better results when associated with the mechanical adequacy provided by brushing, in reducing the cases of nosocomial pneumonia. Other methods such as the use of povidone-iodine and supraglottic aspiration were mentioned, although their effects are still controversial. Thus, we conclude that although there is not a well-defined protocol for the control of oral biofilm and consequent reduction in the prevalence of pneumonia, chlorhexidine associated with brushing seems to be the most promising method. More studies with robust methodology are needed for the understanding and proposal of protocols based on scientific evidence for oral hygiene of patients in intensive care, focused on reducing morbidity and mortality from nosocomial pneumonia.

Soy is the most economically important agricultural crop in the world. Achieving higher productivity has been a challenge in today's agriculture. Making the seed, surely, the most important input for agricultural development, because, as a living organism, it is depositary, directly or indirectly, of a large part of the technological advances developed by researchers over decades. Therefore, the successful implantation of a crop is in the use of seeds of high physiological quality, with a high percentage of germination and vigor. Thirty cultivars and 29 cities were used, totaling 131 samples from the three southern Brazilian states. Being evaluated the physiological quality, as well as its components, germination, accelerated aging at 41ºC for 48 hours, tetrazolium test, and mass of a thousand seeds. For the macronutrient tests, nitrogen (N), phosphorus (P), potassium (K), Calcium (Ca) and Molybdenum (Mo) were analyzed. At the end of this work, it can be concluded that the three states in the south of Brazil did not present differences regarding the physiological quality of the tested cultivars. However, the physiological potential comprises the set of skills that allows estimating the capacity of a batch of seeds to properly manifest their vital functions after sowing.

The aim of this study was a literature review of the current status and recent years of fresh foods such as vegetables, mostly lettuce and kale consumed in natura, emphasizing studies from journals published in the last 20 years considering the presence of microorganisms such as coliforms at 45 ºC, Salmonella ssp, and various fungi. The consumption of fresh foods in recent decades has increased considerably, due to the search for knowledge of the origin of the foods consumed, mainly in vegetables. In small towns, the cultivation and sale of vegetables and vegetables is mostly carried out by families in their small gardens, often outdoors and in the urban area itself, where there may be various risks for the production of these natural foods, such as septic tanks, open sewers and stray animals, for this reason, these plants are subject to contamination by opportunistic microorganisms, such as coliforms at 45 ºC, Salmonella ssp and fungi. Foodborne infections are common and termed foodborne illnesses. These diseases that can lead to death. It is concluded that food quality control is directly linked to health, that is, a product with quality and safety ensures that fewer outbreaks of foodborne diseases occur, substantially avoiding the burden on public health systems.

This study sought to apprehend the experience of women who underwent prenatal care through the Programa Rede Mãe Paranaense Program in two municipalities on the international border strip. This is a qualitative research in the light of the phenomenological reference of Alfred Schütz, conducted with 18 women who were assisted in prenatal care by the program. For data collection, a phenomenological interview was used, and the analysis was followed according to the referential. Five categories were identified: knowledge about the program; access and reception in the health service; multiprofessional care and its peculiarities; health education; and women's perspectives regarding the program. The results point to a practice focused on the medical care model operated in a systematized way with little opening for dialogues, exchange of experiences and information, considering the particularities of the border area and the limitation of the study. Instigates reflections on prenatal care in the face of the program proposal that requires investments in training and actions of professionals.

The present work aims to develop and apply a didactic sequence based on the three pedagogical moments. For this, it was developed for first-year high school classes, with the theme “The Periodic Table and the Human Body”, in the first pedagogical moment, a problem situation involving the subject was taken to the students, as well as questions for surveying prior knowledge. Right after, in the second pedagogical moment of contribution of the board, video, support texts and questions, the content of the periodic table was raised, always linking to the generating theme. Finally, at the last pedagogical moment, a game similar to the super trump was used, The game called: Xenubi, had aspects related to the periodic properties in its cards. And also at this last moment, food packaging was used for students to answer extrapolation questions. The didactic sequence proved to be an important teaching tool, because following the analysis of the results, the students had an effective learning in the end. This teaching tool also promotes debate within the classroom, making students become more citizens. critics and actors in the world in which they live.

The objective of this study was to realize the pharmaceutical service of health tracking of the metabolic syndrome (MS) in servers of a Public University in Belém-PA.The study was a cross-sectional descriptive, composed of servers of both sexes aged between 20 and 74 years, from the collection of sociodemographic and cardiometabolic data and measurement of abdominal circumference (AC) for evaluation of central obesity (CO).  MS was characterized by the aggregation of at least 3/5 components, which are: fasting hyperglycemia, hypertriglyceridemia, high-density lipoprotein (HDL-c) hypolipidemia, arterial hypertension (AH) and CO. For the statistical analysis, the GraphPad Prism® - 5.00-Windows software was used, with Pearson's Correlation Coefficient for sample analysis; Chi-square test for analysis of the presence/absence of MS x Framingham strata; Fisher's Exact Test to evaluate the relative risk. The results showed a mean age of 46±13 years and a majority of women (60.4%) within the sample of 91 servers. There was a predominance of low HDL-c levels (73.6% and p=0.0165); of CO (53.8% and p<0.0001) and AH (50.5%). Among the employees, 48.3% were classified as "Presence of MS", among which there was a predominance in the medium (69.2%) and high (82.6%) strata.  Those classified as "Absence of MS" were predominant in the low-risk stratum (70.9%). The analyses of cardiovascular risk x MS (p<0.0001) and age x MS (p<0.0002) were directly proportional. A high percentage of servers classified as "Presence of MS" was perceived, and the screening proved to be effective in the early detection of the components of MS.

Ethnopharmacology deals with popular knowledge concerning traditional systems of medicine; it consists of information acquired throughout life by the population using medicinal flora as pharmacological study. The aim is to analyze the scientific evidence of health professionals' knowledge of the use of ethnopharmacology as a complementary therapy in primary care. An integrative literature review was conducted using the online search platforms Us National Library of Medicine (PUBMED) and Virtual Health Library (VHL) in the databases LILACS, MEDLINE and BDENF. To construct the research question of the integrative review, the Pico strategy was used, essential for increasing the specificity and conceptual clarity of the situation to be studied, providing results of greater quality and uniqueness.  Articles indexed in national and international journals were selected, provided in full, and studies found in the last 5 years in Portuguese, English and Spanish. The results suggest that although phytotherapy is a beneficial practice for many, there are still factors that act as barriers to the consolidation of this therapy within health services. Therefore, it becomes extremely important to mobilize strategies that can pave the way for the effective implementation of ethnopharmacological practices as an integral part of the users' health management.

The textile industry has developed and grown more and more, with this it has been using more dyes, so a large volume of highly colored and contaminated effluents is generated, these effluents, if discarded without prior treatment in water bodies, can generate environmental problems bass. A simple, efficient and cheap way to carry out the removal of these dyes is using the adsorption technique. With that, the present work intends to demonstrate if passion fruit residues, the seeds, which have low added value, can be used as alternative adsorbents for the treatment of textile effluents. Therefore, the objective of this work was to evaluate the passion fruit seeds as an alternative adsorbent for the Nylosan blue N-BLN textile dye, in addition to evaluating the effect of the ionic strength and pH of the solution on the adsorption efficiency and to evaluate the viability of the desorption process. The adsorption studies were carried out in a fixed bed column using in natura passion fruit residues and subjected to chemical treatments with HCl. The acid treatment increased the biomass adsorption efficiency. The ionic strength had little influence on the adsorption process. The pH influenced the adsorption process, and the best pH value was equal to two. The desorption process was possible to happen, using sodium hydroxide NaOH as an extracting solution. The adsorptive capacity for seeds was 10.2 and 20.2 mg g-1 for biomass in natura and treated with HCl.

Circumscribing the educational field, this article updates, until 2020, information on the main CAPES programs aimed at reducing asymmetries in the Brazilian National Graduate System (SNPG) and the panorama of postgraduate studies in the Legal Amazon - Brazil, aiming at contribute to the reflections on the asymmetries in the SNPG and the approaches of induction strategies. For this purpose, information available on the CAPES institutional website and on the Sucupira Platform were explored. As a result, there was an evolution of postgraduate studies in the Legal Amazon, which in 2020 concentrated 421 programs; most recent, emerging and in consolidation, highlighting the importance of consolidation policies. It was observed that despite the various public policies aimed at consolidating postgraduate studies and reducing asymmetries, over time, there are still marked differences between the regions of the country, especially in the area comprised by the Legal Amazon.

Overview: artisanal fishing is an activity that can harm workers' health, as it exposes fishermen to various weather conditions and high physical effort, leaving them susceptible to infectious diseases, such as intestinal parasites. Objective: identify the highest prevalence of infection by intestinal parasites in fishermen in the northern region of Brazil. Methods: descriptive cross-sectional study, in accordance with the guidelines of the STROBE Declaration, carried out in two fishing colonies in Northern Brazil. Results: we identified the following protozoa: Escherichia Coli, Endolimax Nana, Escherichia Coli, Giardia Lamblia, Iodamoeba Bustschlii. No positive samples for helmintoses were found. Conclusion: among the species of enteroparasitosis investigated in 2019, in the North of Brazil, there was a prevalence (> 50%) of Endolimax Nana in parasitized fishermen.

This article aims to verify the importance of the interview in the process of psychological assessment in the context of traffic. Therefore, a qualitative study was performed with a narrative literature review of articles found in the electronic databases BVS-Psi, Scielo and Google Scholar, and normative resolutions of the Federal Council of Psychology that addressed the theme of Traffic Psychology and Psychological Assessment. Traffic Psychology in Brazil emerged from the need to understand and assess the behavior of drivers in order to contribute to safer traffic. In this sense, psychological assessment became mandatory in the drivers license process and, as a historical consequence, it became the priority activity of traffic psychologists. There is, however, a confusion on the part of many people, including psychologists, between psychological assessment and psychological testing, as many professionals use only psychological tests in the assessment process. It was found that conducting the interview provides more efficiency to the process and greater security of results, supporting the professional's decision-making and making the work ethical, which contributes to transit in the country. It is through the interview that there is the possibility of a broader assessment and greater reliability in the data obtained of the candidate or driver. Thus, it is necessary to constantly update and train the psychologist with regard to the technique and procedures of psychological assessment, so as not to reduce the assessment in testing, so as not to cause harm to the people evaluated or to society.