Repositório RCAAP

Banco Santander S.A.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Sol-gel-obtained pseudoboehmite, an aluminium monohydroxide, is a poorly crystalized, non-metallic, synthetic, inorganic nanomaterial with both high purity level and specific area (SA). Studies are currently beeing carried in order to use it in the controlled liberation of drugs. Drugs of controlled delivery aim at releasing therapeutic dosages of a drug to a certain area of the body, keeping the desired concentration, release speed and adequate retention time as well as maintaining optimal blood levels, thus avoiding, on plasmatic levels, the problem of toxic doses. The present work seeks to obtain Pseudoboehmite of high purity and specific area, key characteristics for its use as support to controlled release of Acyclovir. To this purpose, it is essential to control all variables of the process so that the resulting product displays characteristics such as high performance, process reproducibility, continued stability and consistent physical-chemical properties. The variables to be controlled during synthesis are: raw materials, precipitation technique, reagent content in the reaction radium, precipitation temperature, agitation of the reacting medium, aging condition and specially pH control. Pseudoboehmite nanoparticles were obtained through sol-gel process using aluminum chloride hexahydrate in sodium chloride solution as a precursor and sodium hydroxide. The synthesized samples were characterized by X-Ray Diffraction, Scanning Electron Microscopy, Thermogravimetric Analysis, Differential Thermal Analysis and Adsorption Isotherms, observing the variations in the resulting phases and their relations with the variations of the molar concentrations. The Acyclovir adsorption with the synthesized pseudoboehmite was tested in solutions simulating its dissolution in the gastric juice in HCl 0,1 mol/L (pH 1-2) solution and plasma absortion in the simulation of the intestinal system (H2O and pH 6,5-7,5) and characterized by High Performance Liquid Chromatography. Results show that samples synthesized from 0,5M OH- had characteristic peaks in the X-Ray diagram of the pseudoboehmite structure (boehmite), while samples synthesized with smaller molar concentration (0,4M OH-) had peaks characteristic of the bayerite and boehmite structures. Synthesized samples of 0,5 M de OH- concentrations had specific area greater than 139m2/g on average. We noticed that the sample aging reduces mass loss in 36% on average, as seen in the Thermogravimetry (TG), in the samples and that it is also responsible for 46% increase, on average, of the pseudoboehmite sample in the crystaline phase. The adsorption isotherms show that the non-aged samples had a specific area 106 m2/g bigger than that of non-aged samples. The effects of these results can be seen in the answers regarding the pseudoboehmite study as excipients in the controlled release of Acyclovir, which kept its chemical stability without degrading the pseudoboehmite or drug, rendering the solubilization of the drug.

This research aimed to find contributions to theory can be obtained through interventionist research in implementation of costs and setting prices in small business. The methodology was based on the framework of Labro and Tuomela (2003) and consisted of two phases. The first phase called knowledge sharing was developed based on the concept SECI (Socialization, Externalization, Combination and Internalization) developed by Takeuchi and Nonaka (2008). The second phase, interventionist, also proved successful. It was found that the training phase had a relevant interest in achieving the objectives of the research. It was also found that replication of this methodology requires some important precautions, including: (1) it is necessary to prevent competitors participate in the same training group as well as intervention, (2) it is necessary that researchers have experiences professionals with the theme and the reality of micro and small enterprises, (3) the training phase has to be presented in a language appropriate to the reality of these managers / entrepreneurs. The evidence shows that improvements in cost control were more pronounced in two of the three companies studied. These two companies have controls that may be appropriate and the results suggest that the degree of quality of these controls is influenced by the active participation of a partner in financial control. This allowed the interventions resulted in improvement in controlling costs and selling price. A better understanding of the costs allowed an increase in business confidence in negotiating prices with customers. The results should be analyzed considering the limitations of this study that analyzed a sample of only three small industries located in the metropolitan region of São Paulo city, set in the metallurgical sector, but with different characteristics very similar to the population of small companies. Future research may be conducted using the actual sample of participating companies, which can investigate the benefits of the intervention on a larger interval of time. Sized companies with sales higher levels with better management controls, could to need modern techniques of management control as Balanced Scorecard or Target Costing.

Instituto Presbiteriano Mackenzie

Fundo Mackenzie de Pesquisa

In this study we aimed to perform an analysis of tax incidence in the activities the "third sector". To this end we start from an analysis about what this sector is considered by checking their appearance in Brazil, as in comparative law, especially as regards England, for a time thereafter, presenting critical legal and economics end of the election, demonstrating the difficulty in conceptualizing this particular segment and which is booming, compared to the minimalize state and its difficulty in providing educational and assistance services. Firmed these assumptions we focused our work on the concept of tax immunity, from a historical study of doctrine, thus achieving the largest object of this work that is the analysis of the immunities precepts regarding taxes and social contributions, respectively, contained in Articles 150, section VI, "c", and 195, § 7, both of the 1988 Brazilian Constitution. The analysis in question was based on the current legislation on the subject, doctrine and jurisprudence related and, in the absence of depletion of the topic in the academic and judicial fields, this paper presents the controversial topics, indicating based on research developed, the possible developments of the theme.

Instituto Presbiteriano Mackenzie

Universidade Presbiteriana Mackenzie

This project aims to explore the verbal and non-verbal languages used in publicity campaign ads of a nationwide magazine (VEJA). The publicity presentation of objects of any kind is so powerfull that can, undeniably, be contested. It attracts the readers from all the sides. The statements presented in the messages come to meet the consumer´s expectations, making them happy and believing in the possibilities of having their desires fulfilled. Therefore, the main purpose of this work is to analyze those ads, verifying how both the visual and verbal languages shown in them take part in the reader´s persuading process. To do so, our project considers as theorical base general aspects of the advertising publicity, the word usage in advertising, the argument and Aristóteles and Perelman´s Rhetoric. We also emphasize the importance of the visual aid as an argument component in advertising and the relationships there are between texts and images, supporting the persuading process. The conclusion of this work showed that the publicity argument uses the verbal and visual languages with the intent of persuading the reader.

Fundo Mackenzie de Pesquisa

Discusses the mythical study of the car through the movies passing at the same time by the history of cars using like main basement the theory of Roland Barthes. Reports, understands and gives form to the myth by exploring it as a cultural phenomenon, establishing a relation-ship between the mythical of the car and movies. Shows how the vehicle has an important role in helping to build the characters and the atmosphere of the film. Presents and analyzes vari-ous trends in automotive customization, relating them to the context of contemporary culture and showing them as tools for automotive creation myth. Emphasizes the questions discussed earlier, culminating in a proposal to use the myth as creative element in the design process. Relates to the current design process for permeating concepts as form and function, Gestalt, design thinking, experience design, emotional design, and semantics in product design. It also demonstrates a possible interdisciplinary methodology based on emotional design that adds to existing concepts and methodologies to facilitate the identification or production of myth

O trabalho discorre que a arquitetura não seja capaz de curar uma enfermidade de uma doença como o câncer em questão, é possível que esta seja pensada de forma a amenizar o sofrimento deste usuário que se mostra tão sensível e vulnerável psicologicamente, e projetar um conjunto arquitetônico voltado para as crianças, adolescentes e seus acompanhantes, que são pessoas fragilizadas pela doença e merecem um olhar diferenciado...

This dissertation aims to assert the quality and use potentiality of a building method, designed by the Brazilian/Catalan architect Joan Villá at the Housing Laboratory of the Faculdade de Belas Artes de São Paulo (Fine Arts Faculty of São Paulo / Brazil) and then at the Unicamp (University of Campinas São Paulo/Brazil), where it was specially applied in its Student Housing Campus (Campinas), with the use of the proposed technollogy, simple and easy workable steel framed ceramic pattern. The study takes also in account the importance and value of that experiment and innovation as a contribution to the the Brazilian Architecture as part of Villa´s professional life.

This work analyzes the pictures and the writing in high school History books in accordance with Programa Nacional do Livro Didático (National Textbook Program) PNLD, created by the federal government in 1985. The data from this survey, organized in graphs and tables, identified permanence and changes in the pictures and in the writing of high school History books through a comparative table of the two most sold books to PNLD with four other previous collections published by major publishers, two of them published between 1980 and 1990, when PNLD did not cover History in High School and two other editions published between 1960 and 1970, thus preceding PNLD. Initially we recovered the history of PNLD when it was observed that this program has helped to increase the number of teaching collections and to bring major foreign publishers to Brazil, as the purchase of millions of books which were given for free to all public schools in the country, was guaranteed by the government. This new reality has helped to promote a more careful publishing of textbooks since Basic Education Department, in partnership with federal universities assumed the responsibility to coordinate and evaluate the competing works. Although it was created in 1985, it was only in 2005 that PNLD contemplated History and so far two high school PNLDs were conducted related to it, the first one was between 2007 and 2008 and the other between 2011 and 2012.

The accounting records which have been created based on the owners concern, motivated on his ownership protection and property control, became subject to publicity, as far as the entrepreneurship began to fit the modern corporation feature, what implies in the countries where the capitalism system applies a must for issuing the Balance Sheet and the Annual Income Statement. Due to the growing gap between the book value, which is performed under the Generally Accepted Accounting Principles, and the market value, there comes a need to provide a uniform procedure and a disclosure for that issue in order to report and analyze the available information within a diverse way, which has been the trend to report and announce the corporation valuation and performance. This job seeks reporting some procedures that have been recently performed, informing more properly the stakeholders, concerning the pub-lic corporations, their value in currency, and testing a model based on obtainable open data basis elements.

Fundo Mackenzie de Pesquisa

This work presents a face detection system that uses a Bayesian Network to combine information from different computational cheap visual operators. The aim in this work is to show that combining simple features in a Bayesian Network allows building an enhanced face detector system, increasing the detection rate and speeding up the face detection process. This face detector has been developed to work in the stream acquired by a USB computer camera. After the detector finds a face in the stream, a face tracking system begins to work, locating the eyes position at the screen. The system is part of a high precision optical mouse system that will be used in human-computer interface, helpin users with certain disabilities.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior