Repositório RCAAP

Fundação de Amparo a Pesquisa do Estado de São Paulo

Medicamento é todo produto desenvolvido a partir de fármacos, no intuito de trazer o bem-estar físico, mental e social à população. Para se produzir um medicamento há que se considerar o fármaco utilizado, a quantidade, a qualidade, o manuseio, a produção, ou seja, todo o processo de desenvolvimento e fabricação até sua administração para que não haja danos ao paciente. Neste trabalho o objetivo foi de realizar uma revisão bibliográfica sobre produção de medicamentos estéreis, detalhando o processo de fabricação e administração dos mesmos para que o êxito no tratamento das doenças seja alcançado e também o olhar atento e meticuloso do farmacêutico seja mais apurado em relação aos cuidados com todo o processo. A utilização desses medicamentos requer atenção e são aqui apresentados de forma significativa. A literatura que versa sobre o assunto menciona os diversos métodos de esterilização: métodos, ensaios, avaliação, controle, monitoramento, prazo de validade e validação. Fatores estes que influenciam de modo singular de cada passo na fabricação e administração de um medicamento. Nesse sentido, a fabricação de medicamentos no Brasil é amparada e acompanhada pela Agência Nacional de Vigilância Sanitária (ANVISA) que é responsável pela supervisão dos processos de produção de medicamentos por um farmacêutico. Sendo uma preocupação o acompanhamento de todos as etapas sob o olhar crítico do farmacêutico garantindo a qualidade, esterilidade e eficácia devida do medicamento, assim como o constante estudo sobre a temática para a atualização de acordo com o progresso em que nos encontramos hoje.

As the cities are developing, the amount of bothering sounds there increases considerably, making that the urban noise becomes each more imponent at the sondscape, mainly of the big cities. In this context, the salubrity and the quality of life of the involved populations are highly engaged, it has seen that the sonorous pollution has diverses harmful effects to the man. In this way, this work intends to detach the importance of the acoustics directrixes in the urban planning and in the architectonic project, to be possible to improve the noise attenuation. The first chapter intends to present an overview of the sondscape evolution, showing some of the most history bothering sounds and, after that, to analyze the current urban sonorous landscape. The second chapter presents the main concepts of the acoustics, whose knowledge is basic for the further reading. The third chapter intends to study the urban acoustics barriers, which are the contention barrier that act as interceptors of sonorous waves between the source and the receiver. Finally, the fourth chapter intends to examine the architectonics acoustics barriers, which are forms and dimensions that the building can assume for a better isolation of the external noise.

Universidade Presbiteriana Mackenzie

O trabalho discorre sobre se aprofundar no conhecimento existente da produção de habitações compostas por módulos pré-fabricados, incorporando neste desenvolvimento a sua construção, materialidade, estrutura e estética...

The growth of competitiveness has forced organizations to adapt and reinvent themselves constantly. This context implies directly in reasons found by the individuals to learn, like solving a problem, for example, leading them to use different strategies for the learning process. Learning strategies may be informal, like asking for help to colleagues or reading a technical material. It may be also formal, like attending training programs offered by the company. This study aimed to measure and understand which learning strategies are mostly used according to four different objective identified in the workplace: solving a problem, performing a new task, obtaining autonomy and increasing the growth chances in the company. The sample was consisted of 4632 workers from the production line in an automotive company. A confirmatory factor analysis was performed to ensure the validity and reliability of the measures subsequently, the factor scores were used in the comparisons of the use of each learning strategy for each purpose. The results showed that the learning strategies applied do not differ according to the four objectives presented. Among the surveyed strategies, the most used is interpersonal help-seeking, this means, asking support or information to other people at workplace. Written help-seeking and participation in courses are less applied.

Universidade Presbiteriana Mackenzie

Fundo Mackenzie de Pesquisa

Would be ideal that State had condition to give your people the best possible quality life, people who have illnesses receive the best service available, according to the historic moment of medical science, and environmental circumstances were suitable for development staff. As for all the rights, the implementation of the right to health to health is limited by the state resources, so that the State gives people only what he is able to afford. Strictly speaking, the choice of the State shall deliver to the people should be subject of legislative deliberation. In Addition, there must be an administrative structure for that right actually is assured. The combination of this legislative deliberation with the administrative structure comprises that is called public policy. The dependence on public policy, however, cannot be absolute. Whereas health and other social rights lend themselves to effective civil liberties, there must be a minimum to be provided by the State, by the force of the Federal Constitution. The present dissertation intend to define, with the maximum precision, what constitutes the minimum under the right to health, taking into account the understandings found in the doctrine and jurisprudence, and also compare it with the regulatory infra matter.

In the current management model adopted by FTD Educação, a provider of educational solutions, there is a frequent delay in the delivery of educational content in time for the school service campaign to begin, resulting on the presentation of incomplete educational solutions that hinder the commercialization process. In this context, the objective of this project was to understand, investigate and diagnose potential causes of delays to propose an applicable solution to the company to eliminate the problem. Questionnaires were prepared and applied to the company's managers, and the results revealed a lack of project management methodologies aimed at creative and collaborative products. The lack of methodology forces editorial managers to adopt inefficient processes and systems for coordinating simultaneous projects, which results in production delays and non-compliance with deadlines. To solve the problem, this work proposes the adoption of two agile methodologies (Scrum and Kanban) with sufficient flexibility and adaptability to be applied on FTD Educação's editorial manufacturing. Scrum is a framework for improving the production process and Kanban is a technique that allows better workflow visualization. The adoption of these methodologies by FTD Educação represents an innovation that contemplates cultural and operational changes that involves all organizational levels and will introduce innovations to the production process, like the new work format for the editorial team. As this is a complex change that involves a significant number of employees and possible impacts on the company's operation, this work proposes the adoption of suggested methodologies in two phases. In the first stage there is the execution of a pilot project to assess the real feasibility and effectiveness of the proposal in solving the problem. The second phase considers the evaluation of the results observed in the pilot project to ascertain the need for adjustments and improvements on the Scrum framework and Kanban board for posterior application in other editorial managements. The predicted impact with the adoption of the suggested methodologies is the production of innovative educational content and continuous support to the company's mission of contributing to society through modern and quality educational solutions, helping children and young people to learn.

Universidade Presbiteriana Mackenzie

This dissertation analyzes the issue of social protection of the residents on the street (MSR) considering the possibility of social reintegration and recovery of citizenship of these individuals. Then see how the determinations social, economic, political and cultural, within the contemporary neo-liberal influence in the redefinition of their exclusion. These reflections made on social issues directly involve the idea of breaking what we call a cycle of isolation, lack of formalized production and accumulation of goods and labor. Seeks to deepen the changes in the pattern of coping with the state of poverty, inequality and exclusion, increased by studies on the actions the Federal Constitution of 1988 (social rights and public policies with universalist vision) and other laws under the Constitution, along with an even intense social action organizations (identified in this context, today, quite active early references on poverty in Brazil: a structured ideas of charity and mercy, especially the Catholic Church, in actions that lend themselves to a clear state Social Welfare) Social and Public Policy (now embodied in policies focused in particular on the federal level). It addresses also issues inherently accustomed to civic participation and the attitude of social movements, such as institutional mechanisms to ensure founding principles of freedom and implementing constitutional social rights. It appears, finally, in terms of national analysis, mapping of poverty, inequality and exclusion (2003), drawn from broader concepts of research, showing limitations, advantages and benefits in terms of range of the most reliable real needs social.

Constantemente inserido em situação de possível ruína, o panorâma atual do Teatro Oficina é de sujeição aos órgãos públicos e resistência à uma lógica mundial que concomita com a incessante reconstrução do solo urbano. Em junho de 2018, o Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN) toma frente nas decisões que permitiriam ao Grupo Silvio Santos a construção de um grande conjunto multifuncional nas adjacências do teatro, contrariando o veredito de tombamento emitido pelo órgão em 2010. A luta pelo território foi travada há mais de trinta anos, quando o grupo liderado pelo José Celso Martinez Corrêa conseguiu em 1983, para a sua sobrevivência, o tombamento em nível estadual pelo Condephaat (Conselho de Defesa do Patrimônio Histórico, Arqueológico, Artístico e Turístico). Foram através de incessantes sessões, que os membros conselheiros do Condephaat deram a vitória controversa ao grupo Sisan, de Silvio Santos. Permitiram, em cada voto, a conquista como quem consente com a capitalização do território, com a ressignificação da memória e com a dissolução dos espaços que não domesticam o corpo. ressignificação da memória e com a dissolução dos espaços que não domesticam o corpo. O problema das mutações espaciais, propostas pela citada lógica mundial neoliberal, é que pouco se pensa nas apropriações coletivas dos espaços, suas histórias, microdinâmicas incorporadas e o que os indivíduos desejam que o lugar se torne. Políticas desiguais são estruturadas por cima de ambientes coletivos, provocando brutais desagregações sócio espaciais.

O presente trabalho de monografia tem como objetivo enumerar as hipóteses em que existirá a responsabilidade tributária dos grupos econômicos, com o auxílio dos entendimentos dos Superiores Tribunais bem como com a ajuda dos doutrinadores que manifestam grande conhecimento sobre o tema.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

The economic growth is close linked with the growth of the companies. There is a great expectation that the countries of the supposed block BRIC: Brazil, Russia, India and China presented a vigorous growth in the coming decades. The capital structure of these companies will have a key role in providing more financial resources for the increased activity, necessary for this expected growth. The present study investigated the capital structure of the companies in this supposed economic block, in order to identify its determinants, the influence of governmental policies in their training and the alignment with the main theories of capital structure currently discussed in the literature: agency costs, trade-off, asymmetric information and pecking order. Made a comparison with U.S. companies, the leading country in the world economy, and calculate the level of debt off of the sample. The results identified several variables as determinants of capital structure of companies of the sample, with predominance for the variables at the firm level, and to a lesser degree in the macro-economic level. Strongly corroborated the assumptions of the theories discussed, and provided robust evidence of being aligned with U.S. companies. They also showed a reasonable debt off for countries in the sample, which can be applied to increase de activity of enterprises, except Russia.

This work analyzes the architectural and theoretical production of Rem Koolhaas in the period between 1976 and 2002, therefore since the foundation of his office, OMA. In this process, he seeks to identify in his projects the application and maturation of concepts, principles, or procedures developed initially in his book "Delirious New York: A Retroactive Manifesto". Concepts those that added to others, with later formulation, would define an architecture apparently free from the restrictions of history, ideology and politics. Such freedom would allow architecture to develop on its own terms.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundo Mackenzie de Pesquisa

The performance of a distributed Raman amplifier at C and S bands using the TrueWave Reach LWP fiber in 100 km span is analyzed through numerical simulations. The physical parameters of the fiber, such as, attenuation, dispersion, and Raman gain efficiency for C and S bands were experimentally characterized by the manufacturer, the OFS Denmark. It is required around four pumping lasers to assure an on-off gain of approximately 15dB in 70nm (1500nm to 1570nm), covering operation in the C and S band.