Repositório RCAAP

O Carcinoma Hepatocelular (CHC) é a terceira principal causa de morte relacionada com o cancro no mundo. A invasão microvascular (IVM) é um fator prognóstico essencial nos doentes com CHC e representa uma ferramenta valiosa para a previsão de recorrência e a seleção adequada de tratamento. Neste estudo, retrospetivo analisou-se a importância do desempenho diagnóstico da Ressonância Magnética (RM) na avaliação pré-operatória e previsão de IVM, comparando os resultados RM e histológicos em doentes com CHC utilizando diversos softwares especializados. A amostra foi constituída por incluídos 22 doentes que foram tratados cirurgicamente para CHC no Hospital de Santa Maria, entre abril de 2017 e março de 2022, realizando previamente uma RM abdominal, com contraste extracelular ou hépato-específico. Em relação aos dados demográficos, as variáveis estudadas não demonstraram distribuição normal. Quanto à fiabilidade interobservador, todas as lesões medidas na fase portal, hépato-especifica, bem como todos o ROIs medidos neste estudo, nas sequências T1 em fase e fora de fase, e na sequência T2 mostraram uma consistência excecional (coeficiente >0,950). Na análise da relevância das características de RM preditores de IVM, as medições efetuadas na fase portal, hépato-específica, Washout e a hipervascularidade das lesões demonstraram terem relevância na predição de IVM (p <0.05). Foi observada na maioria das variáveis uma fiabilidade intraobservador excelente (coeficiente >0.900). Não foi possível demonstrar o papel preditor das variáveis significativas na IVM (p = 0,080). Alguns resultados observados neste estudo estão de acordo com a literatura, como as medições das lesões na fase portal, hépato-específico e na análise do Washout e da hipervascularidade das lesões de CHC. Estes achados sugerem que as características de RM apresentam potencial menos invasivo para predizer IVM no doentes com diagnóstico de CHC.

In the German literary landscape of the last decade, the re-emergence of the family novel, both biographical and fictional, should be related to the huge interest in “memory studies” since the early 1990s. Brought into the microcosm of the family circle the difficult German history seems to be more easily understood and through the literary mediation easily transformed into cultural memory (A. Assmann). This article examines Eugen Ruge’s debut novel In Zeiten des abnehmenden Lichts (2011) as a good example of this literary trend. Attention will also turn to the transformation of familial and collective history into memory and it will focus on the way it is done: without “nostalgie” and full of subtle humor.

The aim of this article is to understand the construction of corporeal bi ographies of Brazilian trans women and travestis sex workers who travel to Portugal and/or the European continent. By corporeal biographies we mean the entanglement between the process of body modification and the process of social production of subjectivities during their travels through different social, geographical and historical contexts. The analysis is based on data from comprehensive in-depth interviews with fourteen participants, oriented by a sociology of the individual and the body. Mobility to and through Europe proved to be a significant turning point in their life courses, as it led tothe accumulation of economic, social and cultural capital, which is transformed into different types of body and symbolic capital. At the same time, transnational mobility changes the heritage of dispositions related to gender expressions and models of femininity, which are differentiated by factors defined by the subject’s body and by generational issues. While geographical transits give substance to different corporeal biographies, they all ultimately converge towards the acquisition of symbolic capital, represented by the embodiment of resources and symbols perceived as aspects of glamour and luxury in the European sex work field

A satisfação laboral desempenha um papel crucial no contexto organizacional. Inúmeros estudos têm vindo a mostrar os impactos positivos que a satisfação laboral tem no desempenho, na lealdade, na vontade de permanência, entre outros. Sendo a satisfação laboral uma peça fulcral no contexto organizacional, torna-se essencial compreender os fatores que levam a um indivíduo sentir-se satisfeito. É neste contexto que surge este estudo. Os dados utilizados são provenientes de um questionário realizado aos colaboradores de uma empresa inserida no setor indústria/ retalho, no âmbito de um projeto do Observatório Nacional dos Recursos Humanos (ONRH) em parceria com a Qmetrics. Fez-se uma análise exploratória dos dados e criou-se um modelo de regressão linear múltipla para explicar a satisfação global com a empresa. As variáveis de estudo foram Infraestrutura Laboral, Envolvimento organizacional, Orientação para o cliente, Relacionamentos interpessoais, Autonomia, Reconhecimento, Desenvolvimento profissional, Remuneração/ benefícios e outras variáveis de caracterização.

This essay reflects on the condition of Iphigenia as a Greek woman exiled in a barbarian land, compounded by her situation as a single woman without children, city, or homeland. In short, Euripides' Iphigenia seems to embody the condition of any woman under the status of a servant in a foreign land in Classical Antiquity.

A água é um direito humano. Ainda assim, não está à disposição de uma parte significativa da população mundial. Em 2023, cerca de 2 mil milhões de pessoas não dispunham de água potável. Esta problemática é particularmente grave em África e em países em desenvolvimento como a Guiné-Bissau. O trabalho desenvolvido teve como objetivo principal avaliar a qualidade microbióloga e físico-química da água para consumo em localidades da Região de Oio na Guiné-Bissau, bem como a análise da sua disponibilidade. O estudo foi realizado entre outubro de 2022 e setembro de 2023 em quatro localidades rurais: Cangha N’Tchugal, Cajaque, Infaidi e Insanha. Durante o período foram colhidas e analisadas oito amostras de água por localidade, quatro em cada estação. Os resultados microbiológicos revelaram a presença de coliformes fecais na maioria das amostras, com concentrações entre 2 e 39 UFC/100 mL. Das determinações físico-químicas realizadas destaca-se o pH ácido das águas em todas as localidades, que variou entre 4,93 e 6,58, os fosfatos com concentrações entre 0,23 mg/L e 0,77 mg/L e os valores elevados de ferro na estação seca entre 0,27 e 3,00 mg/L. A análise dos parâmetros permitiu verificar um aumento da concentração de coliformes fecais da estação seca para a estação das chuvas: Cangha N’Tchugal 0 para 4 UFC/100 mL, Cajaque 31 para 47 UFC/100 mL, Infaidi 8 para 33 UFC/100 mL e Insanha 2 para 15 UFC/100 mL, e uma diminuição das concentrações de ferro: Cangha N’Tchugal 0,27 para 0,09 mg/L, Cajaque 0,48 para 0,10 mg/L e Insanha 0,07 para 0,05 mg/L. Conclui-se assim, que a água nos quatro pontos analisados não é adequada para o consumo humano. Perante este contexto, destaca-se a necessidade no futuro de uma monitorização regular dos pontos de água utilizados para consumo e de um maior acesso ao recurso e ao saneamento básico.

Background While the existence of a complex variety of casual sexual relationships (CSRs) has beenacknowledged, studies rarely describe the prevalence of condom use across these relationships or how their hybrid nature, specifically relationship characteristics, affect condom use.This study aims to describe condom use within committed relationships and various types of casual sexual relationships (CSRs), examining the influence of relationship characteristicson condom use among culturally validated relationship types (committed, friends with benefits, hookups, booty call). Methods Emerging adults (N = 728, 18–29 years, M = 22.56; SD = 3.01) completed a survey with four blocks: sociodemographics; brief sexual history; relationships over the previous year; andcurrent relationship, assessing relationship type, ten relationship characteristics (e.g., commitment, emotional and sexual exclusivity, partner acquaintance, sexual involvement) andcondom use (vaginal, oral, and anal), operationalized by three measures (use at lastencounter, likert-type scale and percentage of use). Results The results showed patterns in condom use by relationship type and illuminated how relationshipcharacteristics—grouped into three factors: commitment, intimacy, and sexuality—mediate condom use. Condom use was more frequent in vaginal than anal and oral sex,and less frequent in committed relationships. No significant differences were found in condom use in vaginal sex between committed relationships and hookups, with condom in these relationships being significantly lower than in booty call. Intimacy mediated between all contrasts tested and condom use in vaginal sex, while sexuality mediated between committed vs. CSRs and condom use in anal and oral sex. Conclusions Findings point to the need of considering the diversity of CSRs for understanding condom use and highlight the role of intimacy as a relevant mechanism associated with condom usein vaginal sex and of sexuality in oral and anal sex, which should be taken into considerationin the tailoring of health promoting efforts

A dissertação de mestrado em museografia e museologia que aqui apresentamos pretende contribuir como fundamento para uma proposta de acção museal/educação patrimonial, no contexto da comunicação e memória da identidade cultural de uma colecção de obras de arte pública escultura em espaços públicos de Almada , tendo em conta a sua integração e exposição pública no desenho dos espaços urbanos da cidade. Trata-se de um caso de estudo que analisa a presença in situ de um Corpus de obras e autores que se distinguem como significativos testemunhos documentais de valor histórico, artístico e cultural no percurso diacrónico de setenta anos 1936-2005. Com base na inventariação e historiografia de um conjunto de sessenta e seis espécimes de escultura integrado em espaços exteriores de acessibilidade pública, equacionaremos o seu significado e função, para além das relações de apropriação e fruição que se estabelecem com distintos públicos. No entendimento desse contexto procuraremos apresentar soluções que permitam a sustentável realização de uma interacção educativa museológica, de forma a resgatar o reconhecimento pela valorização, salvaguarda e preservação desse património cultural localizado a ser dado à fruição do público

No summary/description provided

This thesis aims at presenting a proof-theoretical analysis of modal logics. Modal logics extend classical propositional logic by adding to the language operators ′□′ and ′♢ ′ , expressing necessity and possibility. In this work, we will be focusing on the modal logics in the S5-cube, built from the basic modal logic K by considering combinations of certain frame conditions such as reflexivity, symmetry and transitivity. We are interested in the study of sequent systems for this family of logics. The systems we present are based on Gentzen’s calculus G3cp, with two additional pairs of rules for the modal operators and where the language has been extended with labels. These labels annotate formulas denoting worlds in a Kripke-model where they are satisfied. Note that this idea is not limited to sequent calculi, in fact, it has been studied for other formal systems such as natural deduction [2, 3] and tableau [10]. Moreover, labels can represent, not only worlds in a model, but also truth values [28]. We discuss several results that have been obtained in the literature for this family of modal logics, such as admissibility of weakening, contraction, and most notably cut-admissibility, which ensures the subformula property. Furthermore, we investigate proof-search termination strategies, which allows us to obtain countermodels for non-derivable sequents, and prove, via proof-theoretical tools, decidability and the finite model property for the logics in the cube, in particular for K and S4 which we take as a case study.

O estudo do balanço sedimentar das zonas costeiras encontra-se dependente de vários fatores interativos e retroativos, sendo o fornecimento sedimentar crucial para a sua quantificação. Existem diversos métodos que permitam proceder à mesma, sendo que são considerados respetivos fatores (clima, geomorfologia, geologia, ação humana etc.), possibilitando a estimativa do sedimento que é transportado e exportado para o litoral proveniente dos sistemas de drenagem. Na presente temática, os maiores problemas encontram-se associados à escassez de dados fiáveis disponibilizados e à dificuldade em considerar o efeito dos reservatórios sedimentares. O principal objetivo na realização deste trabalho é estimar o potencial do fornecimento sedimentar proveniente da erosão hídrica do solo que drena para a zona costeira de Portugal continental e avaliar o efeito das barragens na retenção deste fornecimento. Deste modo, é pretendido fornecer uma aplicação metodológica coerente a nível nacional. A metodologia abordada consiste na combinação dos modelos RUSLE, para calcular a taxa de erosão do solo, e SDR, para estimar o fornecimento sedimentar às zonas costeiras, tendo sido testadas e validadas algumas variantes referentes aos modelos utilizados. Por sua vez, foram considerados cenários que permitissem mostrar o impacto relativo que determinadas alterações, de natureza antrópica e climática, apresentam nesta temática. Segundo as condições de referência (cartografia de ocupação referente a 2018 e uma erosividade da precipitação representativa de 2014), os resultados permitem inferir que potencialmente sejam debitados 39.3 milhões de ton/ano de sedimento no litoral. Dependendo da litologia aflorante nas bacias, a fração de sedimento de praia poderá reduzir até aos 15% do sedimento total. Nos cenários modelados referentes ao impacto das barragens, ocupação prístina, ocupação de 1990, incêndio extremo, medidas de conservação do solo e evolução da erosividade da precipitação para 2070 apresentaram efeitos relativos no fornecimento sedimentar de -82%, -38%, +6%, +261%, -50%, +10%, respetivamente.

Illumination control in optical systems is very important because it contributes to the overall performance, accuracy, and versatility of optical systems in various applications. For example, the optimization of specimen illumination is a significant factor in achieving high-quality images in microscopy. The Koehler illumination system was created by August Koehler in the late 19th century to be used in microscopes and it is still used for achieving uniform and precise sample illumination in modern scientific light microscopy. This system allows to create a uniform light spot using an extended light source. Uniformity reduces image artifacts and provides high sample contrast. The classical configuration of the system consists of two condenser lenses and an extended light source to illuminate the sample. The motivation for this study was the use of the Koehler illumination system in the scope of ARIEL Space Mission On-Ground Support Equipment (OGSE) development activities in the Institute of Astrophysics and Space Science (IA). ARIEL is a space mission of the European Space Agency (ESA) and will observe at least 1000 known exoplanets. It’s going to be optimized the Koehler Illumination System. This study comprises a full optical system modeling, its design, tolerance analysis and then its practical implementation in the laboratory along with measurements of intensity control. Detailed discussion on the several design and performance intricacies and potential challenges are also presented here. All tasks planned initially were executed and the established goals were met, although existing some conditions.

O estudo do fenómeno do afloramento costeiro tem ganho cada vez mais importância, tendo em conta, o cenário de alterações climáticas, em que vivemos. No caso da costa Oeste da Península Ibérica, foi analisada a variabilidade do afloramento costeiro no período de 1982 a 2021, com especial destaque para os meses de verão (julho, agosto e setembro), quando o afloramento costeiro é geralmente mais intenso e persistente nesta região. Os resultados obtidos dizem respeito às latitudes 37º N, 39º N e 41º N. O índice (IU) utilizado para o estudo deste fenómeno baseou-se na diferença entre a Temperatura da Superfície do Mar, ao largo (15º W) e junto à costa, sendo que, valores de diferença de temperatura positivos, são indicadores prováveis da ocorrência de afloramento costeiro. Verificou-se que os anos de 1998, 2008, 2017, 2019 e 2021, apresentam valores máximos de anomalias positivas do IU, no verão, nas três latitudes referidas. A 37º N, existe um padrão de anomalias importante, nomeadamente em julho, em que, nos primeiros vinte anos, predominam anomalias negativas e nos últimos vinte anos predominam anomalias positivas do IU. Uma outra forma abordada neste estudo para analisar a variabilidade do afloramento costeiro, consistiu no cálculo dastendênciastemporais do IU para os meses de verão e das tendências da temperatura da camada de mistura, na margem ocidental da Península Ibérica, recorrendo a resultados numéricos do modelo HYCOM, entre 2009 e 2019. As tendências temporais do IU mostram que, para a maioria dos anos, os valores dos declives das regressões lineares são positivos, embora estatisticamente pouco significativos. As tendências da temperatura da camada de mistura, mostram que, junto à costa, são geralmente negativas e que, ao largo, são maioritariamente positivas, o que é compatível com a intensificação do afloramento costeiro no período analisado.

The Avenida da Liberdade, in Lisbon, is quoted among the most luxurious streets in the world. This chapter examines the path traversed by this axis, from its opening in the late nineteenth century to the present day. We argue that despite the weaknesses pointed out in its conception, several factors related with centrality, symbolism, prestige and scenography allowed this boulevard to assert itself as the showcase par excellence of the city. Intentionally used by the nineteenth-century bourgeoisie for strolling in, to see and to be seen, in recent decades it has become the favorite stage for luxury and fashion retailing. Exploring this idea is based on a mix of qualitative and quantitative methods designed to address the different dimensions of the problem. While the reconstruction of its role as a promenade for the nineteenth-century flâneur relies on an active reading of scientific and literary texts, its most recent vocation as a showcase of international capital linked to luxury and fashion is founded on empirical work, which includes a survey of stores, interviews with managers of shops and field observation.

In this study, we optimized the dissociation of synovial tissue biopsies for single-cell omics studies and created a single-cell atlas of human synovium in inflammatory arthritis. The optimized protocol allowed consistent isolation of highly viable cells from tiny fresh synovial biopsies, minimizing the synovial biopsy drop-out rate. The synovium scRNA-seq atlas contained over 100,000 unsorted synovial cells from 25 synovial tissues affected by inflammatory arthritis, including 16 structural, 11 lymphoid, and 15 myeloid cell clusters. This synovial cell map expanded the diversity of synovial cell types/states, detected synovial neutrophils, and broadened synovial endothelial cell classification. We revealed tissue-resident macrophage subsets with proposed matrix-sensing (FOLR2+COLEC12high) and iron-recycling (LYVE1+SLC40A1+) activities and identified fibroblast subsets with proposed functions in cartilage breakdown (SOD2highSAA1+SAA2+SDC4+) and extracellular matrix remodeling (SERPINE1+COL5A3+LOXL2+). Our study offers an efficient synovium dissociation method and a reference scRNA-seq resource, that advances the current understanding of synovial cell heterogeneity in inflammatory arthritis.

Car dependency in Portugal shows rapid growth in the last 30 years. The increase on motorization rate, the expansion of motorway network and urban sprawl have contributed to the rapid increase in the importance of using the car for daily journeys, marking a new territorial organisation, less dense and disperse. At the same time, there has been a reduction in the use of public transport, which was unable to compete in terms of speed and response to new demands. In recent years we have seen a profound transformation in the organisation and supply of public transport, as well the development of initiatives for the integration of active modes in daily mobility and to get the car out from city centres. These changes give us a more optimistic outlook for reducing car dependency in Portuguese cities.

The European Union (EU) epitomizes the most ambitious and successful regional integration endeavor in contemporary history. As the EU's authority expanded, so did concerns over its democratic legitimacy. Criticisms of the EU's democratic nature center on the perceived remoteness of its institutions from citizens and the inadequacy of mechanisms for effective scrutiny and opposition within its polity. Considering these democratic challenges and the pivotal role that national parliaments can play in these dynamics, three research questions follow: First, what role do Eurosceptic and Europhile parties play in the communication of EU-related affairs within national parliaments? Second, to what extent is the European Union contested in national parliaments? Finally, what are the most Europeanized topics and what characterizes the content of the European debate within national parliaments? Employing a range of computational content analysis methods, this study delves into the legislative debates in Portugal, Spain, and Ireland, spanning from 1996 to 2018. This thesis’ findings reveal that, contrary to the established narrative, Europhile parties are at the forefront of debates on the European polity. Moreover, the eurozone crisis sparked a heightened moment of debate around European policies, but the polity aspect remained out of the public spotlight. Additionally, the European debate predominantly revolves around socio economic matters, rather than over socio-cultural considerations, at least in these countries. Finally, while the EU is as disputed as other policy areas, challenging the notion of an “opposition deficit”, there is a growing trend of consensus among mainstream parties on European matters. Overall, this thesis sheds light on the distinct roles political parties play in communicating and contesting European affairs, the nature of the European debate and the Europeanization of different policy areas. These insights highlight the role that national parliaments can play in European affairs and their potential contribution to enhance the EU’s democratic legitimacy.

Purpose: To investigate the contributors to self-rated health in people with late-stage Parkinson's disease (PD) and cognitive impairment. Methods: A secondary analysis of baseline data from the international Care of Late-Stage Parkinsonism (CLaSP) cohort study was conducted. Participants with PD and either dementia or mild cognitive impairment or MMSE < 24/30 in the absence of major depression were included if they had completed the EQ-5D-3L assessment (n = 277). Factors associated with self-rated health (EQ-5D-3L Index and Visual Analogue Scale) were investigated through multivariable linear regression. Results: More severe PD (motor and non-motor) was associated with worse self-rated health. The EQ-5D-3L dimensions of Mobility, Self-Care and Usual Activities were almost universally affected; the latter two particularly severely. Being unable to perform usual activities or having moderate to extreme anxiety or depression were significantly associated with EQ-5D-3L Visual Analogue Scale, suggesting these are particularly valued. Worse motor impairment and function and the non-motor symptom domains of mood, perception, sexual function, and miscellaneous (e.g., pain) were associated with worse self-rated health, whereas greater burden of gastrointestinal symptoms was associated with better self-rated health in multivariate analysis. Better self-rated health was associated with recent PD nurse consultation, and higher doses of dopaminergic medication. Conclusion: Improvement of activities of daily living, mood and anxiety should be prioritised in clinical practice, with consideration of perception and sexual function in this population. Recent nurse consultations and higher antiparkinsonian doses are associated with better self-rated health, suggesting there is no room for a therapeutic nihilism in this population of people within a complex phase of PD.

Establishing and nurturing strong patient relations stands as an essential pillar in the framework of UEG. Within Europe's diverse healthcare landscape, fostering strong relations and collaboration among the digestive health community will not only optimize healthcare outcomes but also establish solidarity and mutual understanding between healthcare professionals, patients, and patient advocates. By prioritizing patient-centered approaches in our advocacy efforts, and recognizing patient advocates as active partners, we ensure that healthcare services are tailored to meet individual needs and preferences. With these considerations in mind, at UEG Week 2023 in Copenhagen, UEG launched the Digestive Health Roundtable, a new format of dialog between experts in digestive health and dedicated patient advocates. This event marked the first in a series of multidisciplinary meetings, all driven by a shared purpose—to address challenges, identify opportunities and reach consensus on joint actions aimed at improving digestive health across Europe.

'WHEN OTHERS COLLABORATE IN ARTISTIC PRACTICE ...' This study is in the context of artistic practices and collaborative process with local communities and other subject not necessarily related to anthropology. It mainly concerns the direct relationship with the place and the community involvement in the creative process.In this context we study how participants contribute in the process and influence artistic creation, in particular the projects under study, "The Party is Over" and "Next Village", made in a self-built neighborhood on the suburbs of Lisbon and in a village situated on countryside of Portugal