RCAAP Repository

Fundo Mackenzie de Pesquisa

Fundo Mackenzie de Pesquisa

The nanotechnology research progressed significantly over the past 30 years, allowing for the development of new materials with applications that meet the interests of various sectors. In health, the pharmaceutical industry has used nanostructured materials to develop the release of drugs. Application of the nanoparticles offers numerous advantages compared to conventional release, such as progressive and controlled release of drugs from the matrix degradation, effective plasma levels with less fluctuation over time, less risk of toxicity, biological penetration through the barriers and targeting to specific tissue targets. In this study, the material used in drug delivery is pseudoboehmite. This is an oxyhydroxide of aluminum and consists of a structure similar to boehmite. With its production by sol-gel process, starting from high purity reagents, it is possible to obtain high-purity pseudoboehmite with high specific area and with total absence of contaminants, making it therefore promising for applications in controlled release of drugs. In view of the possible use of pseudoboehmite as carriers for controlled drug delivery, this study aimed to determine its acute (50mg/kg, 300mg/kg and 2000mg/kg) and. subacute toxicity (1000mg/kg) in male rats (Wistar rats). The methodology consisted of toxicity tests from the evaluations and analyzes of the biochemical and histopathological parameters resulting from its administration. Finally, the pseudoboehmite was tested in vivo as possible releasing controlled drug acyclovir. In both tests, the administration has not determined mortality in groups and histopathological evaluation of the livers of the animals were not observed any changes in tissue integrity. These readings showed there to absorption of the acyclovir systemic circulation in animals receiving the pseudoboehmite. The readings were taken with a high performance liquid chromatography showed that there was absorption of acyclovir systemic circulation in animals receiving the pseudoboehmite with acyclovir. Acyclovir administered with pseudoboehmite was absorbed from the gastrointestinal tract. The results showed that the pseudoboehmite has low toxicity at high doses of short and falls under the category of nontoxic; the absence of aluminum in the plasma samples emphasizes the absence of aluminum absorption into the systemic circulation and acyclovir present in the plasma of rats allowed confirm that this is present in the systemic circulation of animals even after the steps of the desorption of pseudoboehmite.

Fundo Mackenzie de Pesquisa

Universidade Presbiteriana Mackenzie

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

This paper presents an analysis of the constitutional right to health as a social right, as well as consumer rights as provided by the private sector as supplemental to the provision of services directly by the state. The analysis is about the general and specific consumer s rules for the private health sector, as well as statistics and case studies that demonstrate the growing membership of private health insurance by the Brazilian population as well as the constant violation of the rules imposed on the sector by the plans operators. Being the health a subject of public relevance although provided by the private sector, suffers strong supervision and regulation of the state, with specific regulatory agency, established. Then we analyze the quality of the supervision of the National Health Agency, as well as the judiciary in ensuring the right to health as a social right and the right of the consumer, which should result in the reduction of the demand for the judiciary about issues related to sector.

The study of organizational values has been coming to light through the theories of personal and cultural values, giving the possibility that organizational values be constructed by both reasons. This research has have for proposal to analyze the relation among organization values, based on personal and cultural ones, trying to provide the knowledge of the shared values from individuals into the organizations in order to get the goals. The research characterized itself as descriptive and exploratory, using a quantitative method and two research tools: the Inventory of Organizational Values (IVO) and the Inventory of Profiles of Organizational Values (IPVO). These questionnaires were applied to 324 respondents from a public company and 256 respondents from a state-owned one. The data were treated by statistical techniques and the obtained results brought the light that the study of organizational values both approaches personal and cultural ones are complementary to each other and come up with new ones, which could turn possible to enhance studies of organizational values.

The building-churches manifest a visible and invisible reality. The church made of stone is a symbol of the church made of people who gather to celebrate and like the stones of the building, form a unity in Christ. This unity is expressed in the organization of spaces, especially inside the church where the Catholic church’s liturgical actions take place. The way in which the community is disposed in the space also manifests the level of involvement, of participation in actions that are developed from poles or centralities: altar, ambo, chair of the presidency, baptismal font. The organization of informal spaces from the beginning of Christianity, favored the assembly, the community meeting and participation. Over time, they were replaced by spaces with a clear separation between clergy and faithful. The celebration, a community act, became an action of the elders, carried out alone, without the participation of the community and the poles lost their centrality and were overshadowed by the excess of decorativism and images. The Liturgical Movement emerged in the Church in the early 1900s and the Second Vatican Ecumenical Council was held between 1962-1965. These were two key moments in the Church that promoted the general reform of the liturgy in order to return to the meaning of community celebration, the meaning of being Church. The spaces have also undergone countless changes under the same umbrella: promoting participation, giving back to the celebratory poles their centralities, promoting noble simplicity more than sumptuousness. In the analysis of the churches, aspects of modern architecture, specific characteristics and the values a re presented from the perspective of each architect: Hans Broos, Paulo Archias Mendes da Rocha, Lina Bo Bardi, João da Gama Filgueiras Lima, Francisco Segnini and Joaquim Barretto. We look more carefully at the analysis of spaces as inducers of participation and communion and symbolically configured to show the communion of all in Christ, a guaranteed presence in the celebratory assembly.

Fundo Mackenzie de Pesquisa

The focus on the dissertation will be to examine the actions taken by the regulatory body of the National Financial System, the central bank of Brazil in face of the technological innovations that cross the financial sector in the 21st century. To achieve it, a diagnosis is made of the impacts caused by Fintechs in the financial market and the regulator’s perceptions about positive factors and the new sources of uncertainties or challenges that can affect financial stability. Regarding to the new scenario, this paper aims to contribute to the discussion about central bank’s roles which is the main monetary authorities of the country with the function of basing the role of regulating the financial system, avoiding that market failures appear with the changes originated by the new financial ecosystem. In order to unveil the challenges of the Brazilian central bank into the face of the disruptive movement, the actions taken by the international regulatory agencies and the first action taken internally by the central bank’s technological movements of the main centers for the propagation of financial products and services through the platforms electronic credit or named Fintechs Credit. It is concluded that the actions taken so far, BC of Brazil has been acting prudently and conservatively ways regarding to the new rearrangement due to nowadays, this issues are in tremendous boom in the financial market and any regulatory movement created that improved efficiency, could end up some technological changes in the financial sector and "scratching" the credibility of Brazil's central bank.

The aim of this research is to highlight the work of the architect Paulo Mendes da Rocha in the field of scenography for the theater and opera. Since the 1990’s, the architect’s production has been consistent although little known, especially that in partnership with director Bia Lessa, designing mobile stage settings having great symbolic impact. We will cover the seven scenarios designed by the architect seeking to under­stand the procedures and concepts contained in his creation process. The studies will be elaborated in an individual way and, from the understand­ing of the parties, we will try to understand the whole, debugging the way in which the architect thought about the space in architecture and in another materiality.

This work is a technical report of the analysis process with proposal of intervention for optimization of the operating and management processes of Viação Miracatiba, an urban transport company that operates in the metropolitan region of São Paulo. For the diagnosis, surveys were conducted with employees and clients and a survey of operational performance indicators. The following problems were mainly found: high absenteeism index measured by the number of absences and delays, low level of service measured by the high number of complaints and high operational cost, especially the cost of labor. After analyzing the causes and possible solutions, as well as the future challenges of regulation and technological changes, a plan of actions involving changes in internal policy, adjustment in operational procedures, new recruitment criteria, training and innovation actions was proposed and implemented. In the form of charging the fee with the gradual replacement of the collector by the electronic ratchet. Emphasis is given to the complexity faced to carry out this work since, from its inception, there was involvement of the employees, shareholders, management body and clients. After the implementation of the proposed actions, the indicators show a significant improvement in all dimensions analyzed, with emphasis on innovations in processes that resulted in greater efficiency, reduction of absenteeism, greater profitability due to the cost of labor and higher customer satisfaction, noting that the actions implemented created value for customers and shareholders. Finally, it is understood that the processes and methods presented that have proven effective for improving performance and competitiveness may be references to other companies in the industry or even outside it, which gives the work value both academic and practical, given the its potential for replicability in other organizations.

Executive functions (EFs) involve processes and skills that are responsible for monitoring andhandling information necessary for the execution of complex tasks. In this sense, it is relevant to know about the functioning and development of these skills. For this to be pssible it isnecessary to search appropriate instruments psychometrically to assess and meet the development of EFs. The aim of this study was to verify evidence of validity and reliability of a battery of computerized tests that measure separately the three components of the EFs (working memory, cognitive flexibility and inhibitory control) in children 4 to 10 years old. The study was divided into two sections. In the first section we investigated the evidence of validity for content by a questionnaire submitted to judges, experts in the field. There was agreement among the judges as to the aspects: consistency of the constructs, appropriateness of activities for children, the layout, record, audio, instructions, training phases, the interruption rules and how to record the results . In the second part it sought evidence of validity for relation to internal and external variables, through the participation of 51 children aged 4 to 10 years, enrolled in regular network in the city of Goiania. children were subjected to computerized test (TAFE) and also to the tests: Corsi Block, subtest digits forward and reverse order, Trail Making Test, Stroop Test and Semantic. The Kruskal-Wallis analysis for the age effect showed statistically significant results in working memory and inhibitory control tests and in some stages of cognitive flexibility test. The Spearman correlation between the performances in computerized and traditional tests showed significant correlation between most tests. Trusts evidence were investigated by means of test-retest in 10 children previously submitted to TAFE, the results indicated stability of scores over time. Statistical analyzes performed indicate psychometric adequacy of the instrument.

Organisme fédéral de protection du patrimoine culturel brésilien, l Institut du Patrimoine Historique et Artistique National, IPHAN, a fait les premières recherches sur l architecture brésilienne et à partir de là, a sélectionné les principaux monuments historiques du pays. Dans l Etat de São Paulo, l architecte Luis Saia a été son principal collaborateur, en consacrant sa vie à la défense du patrimoine, dans ses formes les plus diverses. En analysant la production de Saia, nous cherchons à comprendre son idée de patrimoine dans la période entre 1932 et 1975. Ce travail a donc pour objet de contribuer à l'étude de la préservation du patrimoine au Brésil.

The discussion about international borders has increased since the 1990s both at the national and international levels, especially face to the local relations of these realities in a context of supranational interests and conflicts. Brazilian border, Ponta Porã, in Mato Grosso do Sul State, is separated from its twin-town, Pedro Juan Caballero, in Paraguay, by means of a strip Linha Internacional (International Strip). On the basis of the understanding of the peculiar aspects of border cities and of the recent urban policy in Brazil (Constituição Federal of 1988 and Estatuto da Cidade of 2001), the objective of this study is to discuss the Plano Diretor Participativo (Participative Direction Planning), of Ponta Porã - 2006, and its interface with the Paraguayan town. The historical formation of this reality, the analysis of the interactions in the frontier space and the identification of the region conflicts and potentialities made up the basis for this study to analyze not only the aspects of the Plano Diretor, which incorporate the international border, but also its challenges face to the articulation of urban policy with other instruments at the national level, so that conflicts may be equated and solutions for this reality may be devised.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundo Mackenzie de Pesquisa

The automotive industry uses infinity of different products and articles based on vulcanized rubber and, during the manufacturing, part of them are discarded due to the processing failures, causing damage to the environment. If these failures occur after the vulcanization of the rubber, there is no possibility of reprocessing the material. Due to the high cost of the raw materials, reusing the material from vulcanized pieces discarded can generate a reduction in the raw materials, as well as in the final cost of the formulation. Among the rubbers used to obtain these devices, the ethylene-propylene- diene monomer (EPDM) and nitrile rubber containing poly (vinyl chloride) (NBR-PVC) are included. This study aims to obtain and characterize EPDM rubber compound, vulcanized with sulfur containing different concentrations of waste ground vulcanized rubber (EPDM or mixed EPDM/NBR-PVC), observing possible changes in mechanical properties and in relation to chemical compounds without the addition of waste. Compounds were obtained containing 0wt%, 5wt% and 10wt%of ground vulcanized rubber waste. By checking the results, it was verified that the compounds containing different types of waste (EPDM or mixed EPDM/NBR-PVC), at concentrations 5wt% to 10wt% of waste, are more resistant to heat, oil immersion and coolant liquid (ethylene glycol), compared to the compound obtained without addition of waste rubber. The compounds without residue showed better surface finish compared to compounds containing waste. Comparing the surface finish of compounds containing the residue, it was observed that the surface finish obtained from the pressed samples was better than the finish obtained for the extruded samples.

Fundo Mackenzie de Pesquisa