RCAAP Repository
Castration-resistant prostate cancer: mechanisms, targets, and treatment
Patients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC. This great investment has turned into a more rational approach to the development of new drugs. Some of the new treatments are already available to our patients outside clinical trials and may include inhibitors of androgen biosynthesis; new chemotherapy agents; bone-targeted therapy; and immunotherapy. This paper aims to review the mechanisms of prostate cancer resistance, possible therapeutic targets, as well as new options to treat CRPC.
2025-10-28T12:11:44Z
Amaral, Teresa Macedo, Daniela Fernandes, Isabel Costa, Luis
Avelumab as first-line maintenance treatment in locally advanced or metastatic urothelial carcinoma
This work provides a summary of guideline recommendations and an expert position on the use of maintenance avelumab therapy based on a review of current international clinical practice guidelines for locally advanced or metastatic urothelial carcinoma (UC). A PubMed literature search was conducted in March 2022 (updated in July 2023) to identify guidelines for locally advanced or metastatic UC. An expert panel (four oncologists and one urologist) reviewed the guidelines and clinical evidence, and discussed practical questions regarding the use of avelumab maintenance therapy in this clinical setting. The National Comprehensive Cancer Network, European Association of Urology and European Society for Medical Oncology guidelines recommend first-line cisplatin-containing chemotherapy for cisplatin-eligible patients, carboplatin-gemcitabine for cisplatin-ineligible patients who are fit for carboplatin, or immunotherapy with programmed death ligand-1 (PD-L1) inhibitors (e.g. atezolizumab) in platinum-ineligible patients. Maintenance avelumab is recommended in patients with response/stable disease following chemotherapy (regardless of PD-L1 status). In patients who relapse after/during chemotherapy, options include immunotherapy, erdafitinib [in those with fibroblast growth factor receptor (FGFR) mutations], enfortumab vedotin or further chemotherapy. The expert panel provided the following practical guidance: (1) consider maintenance avelumab in all eligible patients; (2) continue avelumab until disease progression/unacceptable toxicity; (3) ideally, administer six cycles of platinum-based chemotherapy prior to maintenance avelumab; (4) perform radiological evaluation after four chemotherapy cycles and prior to maintenance avelumab; (5) carboplatin-gemcitabine followed by maintenance avelumab is preferred in cisplatin-ineligible patients (regardless of PD-L1 expression), but consider first-line immunotherapy in PD-L1-positive patients and platinum-ineligible patients (regardless of PD-L1 status); and (6) for patients who relapse on avelumab, second-line options include enfortumab vedotin, FGFR inhibitors (in those with FGFR mutations) or clinical trial inclusion. In conclusion, avelumab maintenance therapy is recommended following platinum-based chemotherapy in all eligible patients with locally advanced or metastatic UC, continued until disease progression or unacceptable toxicity.
2025-10-28T12:14:28Z
Mansinho, André Cruz, Andreia Marconi, Lorenzo Pinto, Cidália Augusto, Isabel
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update
Objectives: To provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field. Methods: An international task force was formed and solicited three systematic literature research activities on safety and efficacy of disease-modifying antirheumatic drugs (DMARDs) and glucocorticoids (GCs). The new evidence was discussed in light of the last update from 2019. A predefined voting process was applied to each overarching principle and recommendation. Levels of evidence and strengths of recommendation were assigned to and participants finally voted on the level of agreement with each item. Results: The task force agreed on 5 overarching principles and 11 recommendations concerning use of conventional synthetic (cs) DMARDs (methotrexate (MTX), leflunomide, sulfasalazine); GCs; biological (b) DMARDs (tumour necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab including biosimilars), abatacept, rituximab, tocilizumab, sarilumab and targeted synthetic (ts) DMARDs, namely the Janus kinase inhibitors tofacitinib, baricitinib, filgotinib, upadacitinib. Guidance on monotherapy, combination therapy, treatment strategies (treat-to-target) and tapering in sustained clinical remission is provided. Safety aspects, including risk of major cardiovascular events (MACEs) and malignancies, costs and sequencing of b/tsDMARDs were all considered. Initially, MTX plus GCs is recommended and on insufficient response to this therapy within 3-6 months, treatment should be based on stratification according to risk factors; With poor prognostic factors (presence of autoantibodies, high disease activity, early erosions or failure of two csDMARDs), any bDMARD should be added to the csDMARD; after careful consideration of risks of MACEs, malignancies and/or thromboembolic events tsDMARDs may also be considered in this phase. If the first bDMARD (or tsDMARD) fails, any other bDMARD (from another or the same class) or tsDMARD (considering risks) is recommended. With sustained remission, DMARDs may be tapered but should not be stopped. Levels of evidence and levels of agreement were high for most recommendations. Conclusions: These updated EULAR recommendations provide consensus on RA management including safety, effectiveness and cost.
2025-10-28T12:29:40Z
Smolen, Josef S. Landewé, Robert B. M. Bergstra, Sytske Anne Kerschbaumer, Andreas Sepriano, Alexandre Aletaha, Daniel Caporali, Roberto Edwards, Christopher John Hyrich, Kimme L. Pope, Janet E. de Souza, Savia Stamm, Tanja A. Takeuchi, Tsutomu Verschueren, Patrick Winthrop, Kevin L. Balsa, Alejandro Bathon, Joan M. Buch, Maya H. Burmester, Gerd R. Buttgereit, Frank Cardiel, Mario Humberto Chatzidionysiou, Katerina Codreanu, Catalin Cutolo, Maurizio den Broeder, Alfons A. El Aoufy, Khadija Finckh, Axel Fonseca, João Eurico Gottenberg, Jacques-Eric Haavardsholm, Espen A. Iagnocco, Annamaria Lauper, Kim Li, Zhanguo McInnes, Iain B. Mysler, Eduardo F. Nash, Peter Poor, Gyula Ristic, Gorica G. Rivellese, Felice Rubbert-Roth, Andrea Schulze-Koops, Hendrik Stoilov, Nikolay Strangfeld, Anja van der Helm-van Mil, Annette van Duuren, Elsa Vliet Vlieland, Theodora P. M. Westhovens, René van der Heijde, Désirée
Diagnostic delay in amyotrophic lateral sclerosis
Background: Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disease, and the time from symptom onset to diagnosis remains long. With the advent of disease-modifying treatments, the need to identify and diagnose ALS in a timely fashion has never been greater. Methods: We reviewed the literature to define the severity of ALS diagnostic delay, the various factors that contribute to this delay (including patient and physician factors), and the role that site of symptom onset plays in a patient's diagnostic journey. Results: Diagnostic delay is influenced by general practitioners' lack of recognition of ALS due to disease rarity and heterogenous presentations. As a result, patients are referred to non-neurologists, have unnecessary diagnostic testing, and may ultimately be misdiagnosed. Patient factors include their illness behavior-which impacts diagnostic delay-and their site of symptom onset. Limb-onset patients have the greatest diagnostic delay because they are frequently misdiagnosed with degenerative spine disease or peripheral neuropathy. Conclusion: Prompt ALS diagnosis results in more effective clinical management, with earlier access to disease-modifying therapies, multidisciplinary care, and, if desired, clinical trial involvement. Due to lack of commercially available ALS biomarkers, alternative strategies to identify and triage patients who likely have ALS must be employed. Several diagnostic tools have been developed to encourage general practitioners to consider ALS and make an urgent referral to ALS specialists, bypassing unnecessary referrals to non-neurologists and unnecessary diagnostic workup.
2025-10-28T12:27:00Z
Gwathmey, Kelly G. Corcia, Philippe McDermott, Chris J. Genge, Angela Sennfält, Stefan Carvalho, Mamede Ingre, Caroline
Genetic variability in sporadic amyotrophic lateral sclerosis
With the advent of gene therapies for amyotrophic lateral sclerosis (ALS), there is a surge in gene testing for this disease. Although there is ample experience with gene testing for C9orf72, SOD1, FUS and TARDBP in familial ALS, large studies exploring genetic variation in all ALS-associated genes in sporadic ALS (sALS) are still scarce. Gene testing in a diagnostic setting is challenging, given the complex genetic architecture of sALS, for which there are genetic variants with large and small effect sizes. Guidelines for the interpretation of genetic variants in gene panels and for counselling of patients are lacking. We aimed to provide a thorough characterization of genetic variability in ALS genes by applying the American College of Medical Genetics and Genomics (ACMG) criteria on whole genome sequencing data from a large cohort of 6013 sporadic ALS patients and 2411 matched controls from Project MinE. We studied genetic variation in 90 ALS-associated genes and applied customized ACMG-criteria to identify pathogenic and likely pathogenic variants. Variants of unknown significance were collected as well. In addition, we determined the length of repeat expansions in C9orf72, ATXN1, ATXN2 and NIPA1 using the ExpansionHunter tool. We found C9orf72 repeat expansions in 5.21% of sALS patients. In 50 ALS-associated genes, we did not identify any pathogenic or likely pathogenic variants. In 5.89%, a pathogenic or likely pathogenic variant was found, most commonly in SOD1, TARDBP, FUS, NEK1, OPTN or TBK1. Significantly more cases carried at least one pathogenic or likely pathogenic variant compared to controls (odds ratio 1.75; P-value 1.64 × 10-5). Isolated risk factors in ATXN1, ATXN2, NIPA1 and/or UNC13A were detected in 17.33% of cases. In 71.83%, we did not find any genetic clues. A combination of variants was found in 2.88%. This study provides an inventory of pathogenic and likely pathogenic genetic variation in a large cohort of sALS patients. Overall, we identified pathogenic and likely pathogenic variants in 11.13% of ALS patients in 38 known ALS genes. In line with the oligogenic hypothesis, we found significantly more combinations of variants in cases compared to controls. Many variants of unknown significance may contribute to ALS risk, but diagnostic algorithms to reliably identify and weigh them are lacking. This work can serve as a resource for counselling and for the assembly of gene panels for ALS. Further characterization of the genetic architecture of sALS is necessary given the growing interest in gene testing in ALS.
2025-10-28T12:27:13Z
Van Daele, Sien Hilde Moisse, Matthieu van Vugt, Joke J. F. A. Zwamborn, Ramona A. J. van der Spek, Rick van Rheenen, Wouter Van Eijk, Kristel Kenna, Kevin Corcia, Philippe Vourc'h, Patrick Couratier, Philippe Hardiman, Orla McLaughin, Russell Gotkine, Marc Drory, Vivian Ticozzi, Nicola Silani, Vincenzo Ratti, Antonia Carvalho, Mamede Mora Pardina, Jesús S. Povedano, Monica Andersen, Peter M. Weber, Markus Başak, Nazli A. Shaw, Chris Shaw, Pamela J. Morrison, Karen E. Landers, John E. Glass, Jonathan D. van Es, Michael A. van den Berg, Leonard H. Al-Chalabi, Ammar Veldink, Jan Van Damme, Philip
Therapeutic targeting of ALS pathways: refocusing an incomplete picture
Numerous potential amyotrophic lateral sclerosis (ALS)-relevant pathways have been hypothesized and studied preclinically, with subsequent translation to clinical trial. However, few successes have been observed with only modest effects. Along with an improved but incomplete understanding of ALS as a neurodegenerative disease is the evolution of more sophisticated and diverse in vitro and in vivo preclinical modeling platforms, as well as clinical trial designs. We highlight proposed pathological pathways that have been major therapeutic targets for investigational compounds. It is likely that the failures of so many of these therapeutic compounds may not have occurred because of lack of efficacy but rather because of a lack of preclinical modeling that would help define an appropriate disease pathway, as well as a failure to establish target engagement. These challenges are compounded by shortcomings in clinical trial design, including lack of biomarkers that could predict clinical success and studies that are underpowered. Although research investments have provided abundant insights into new ALS-relevant pathways, most have not yet been developed more fully to result in clinical study. In this review, we detail some of the important, well-established pathways, the therapeutics targeting them, and the subsequent clinical design. With an understanding of some of the shortcomings in translational efforts over the last three decades of ALS investigation, we propose that scientists and clinicians may choose to revisit some of these therapeutic pathways reviewed here with an eye toward improving preclinical modeling, biomarker development, and the investment in more sophisticated clinical trial designs.
2025-10-28T12:17:04Z
Maragakis, Nicholas J. Carvalho, Mamede Weiss, Michael D.
The bioelectrical impedance analysis [BIA] international database: aims, scope, and call for data
Background: Bioelectrical impedance analysis (BIA) is a technique widely used for estimating body composition and health-related parameters. The technology is relatively simple, quick, and non-invasive, and is currently used globally in diverse settings, including private clinicians' offices, sports and health clubs, and hospitals, and across a spectrum of age, body weight, and disease states. BIA parameters can be used to estimate body composition (fat, fat-free mass, total-body water and its compartments). Moreover, raw measurements including resistance, reactance, phase angle, and impedance vector length can also be used to track health-related markers, including hydration and malnutrition, and disease-prognostic, athletic and general health status. Body composition shows profound variability in association with age, sex, race and ethnicity, geographic ancestry, lifestyle, and health status. To advance understanding of this variability, we propose to develop a large and diverse multi-country dataset of BIA raw measures and derived body components. The aim of this paper is to describe the 'BIA International Database' project and encourage researchers to join the consortium. Methods: The Exercise and Health Laboratory of the Faculty of Human Kinetics, University of Lisbon has agreed to host the database using an online portal. At present, the database contains 277,922 measures from individuals ranging from 11 months to 102 years, along with additional data on these participants. Conclusion: The BIA International Database represents a key resource for research on body composition.
2025-10-28T12:28:07Z
Silva, Analiza M Campa, Francesco Stagi, Silvia Gobbo, Luís A. Buffa, Roberto Toselli, Stefania Silva, Diego Augusto Santos Gonçalves, Ezequiel M. Langer, Raquel D. Guerra-Júnior, Gil Machado, Dalmo R. L. Kondo, Emi Sagayama, Hiroyuki Omi, Naomi Yamada, Yosuke Yoshida, Tsukasa Fukuda, Wataru Gonzalez, Maria Cristina Orlandi, Silvana P. Koury, Josely C. Moro, Tatiana Paoli, Antonio Kruger, Salome Schutte, Aletta E. Andreolli, Angela Earthman, Carrie P. Fuchs-Tarlovsky, Vanessa Irurtia, Alfredo Castizo-Olier, Jorge Mascherini, Gabriele Petri, Cristian Busert, Laura K. Cortina-Borja, Mario Bailey, Jeanette Tausanovitch, Zachary Lelijveld, Natasha Ghazzawi, Hadeel Ali Amawi, Adam Tawfiq Tinsley, Grant Kangas, Suvi T. Salpéteur, Cécile Vázquez-Vázquez, Adriana Fewtrell, Mary Ceolin, Chiara Sergi, Giuseppe Ward, Leigh C. Heitmann, Berit L. da Costa, Roberto Fernandes Vicente-Rodriguez, German Cremasco, Margherita Micheletti Moroni, Alessia Shepherd, John Moon, Jordan Knaan, Tzachi Müller, Manfred J. Braun, Wiebke García‐Almeida, José M. Palmeira, António L. Santos, Inês Larsen, Sofus C. Zhang, Xueying Speakman, John R. Plank, Lindsay D. Swinburn, Boyd A. Ssensamba, Jude Thaddeus Shiose, Keisuke Cyrino, Edilson S. Bosy-Westphal, Anja Heymsfield, Steven B. Lukaski, Henry Sardinha, Luís B. Wells, Jonathan C. Marini, Elisabetta
Standardised exercise prescription for patients with chronic coronary syndrome and/or heart failure: a consensus statement from the EXPERT working group
Whereas exercise training, as part of multidisciplinary rehabilitation, is a key component in the management of patients with chronic coronary syndrome (CCS) and/or congestive heart failure (CHF), physicians and exercise professionals disagree among themselves on the type and characteristics of the exercise to be prescribed to these patients, and the exercise prescriptions are not consistent with the international guidelines. This impacts the efficacy and quality of the intervention of rehabilitation. To overcome these barriers, a digital training and decision support system [i.e. EXercise Prescription in Everyday practice & Rehabilitative Training (EXPERT) tool], i.e. a stepwise aid to exercise prescription in patients with CCS and/or CHF, affected by concomitant risk factors and comorbidities, in the setting of multidisciplinary rehabilitation, was developed. The EXPERT working group members reviewed the literature and formulated exercise recommendations (exercise training intensity, frequency, volume, type, session and programme duration) and safety precautions for CCS and/or CHF (including heart transplantation). Also, highly prevalent comorbidities (e.g. peripheral arterial disease) or cardiac devices (e.g. pacemaker, implanted cardioverter defibrillator, left-ventricular assist device) were considered, as well as indications for the in-hospital phase (e.g. after coronary revascularisation or hospitalisation for CHF). The contributions of physical fitness, medications and adverse events during exercise testing were also considered. The EXPERT tool was developed on the basis of this evidence. In this paper, the exercise prescriptions for patients with CCS and/or CHF formulated for the EXPERT tool are presented. Finally, to demonstrate how the EXPERT tool proposes exercise prescriptions in patients with CCS and/or CHF with different combinations of CVD risk factors, three patient cases with solutions are presented.
2025-10-28T12:22:48Z
Hansen, Dominique Beckers, Paul Neunhäuserer, Daniel Bjarnason-Wehrens, Birna Piepoli, Massimo F. Rauch, Bernhard Völler, Heinz Corrà, Ugo Garcia-Porrero, Esteban Schmid, Jean-Paul Lamotte, Michel Doherty, Patrick Reibis, Rona Niebauer, Josef Dendale, Paul Davos, Constantinos H. Kouidi, Evangelia Spruit, Martijn A. Vanhees, Luc Cornelissen, Véronique Edelmann, Frank Barna, Olga Stettler, Christoph Tonoli, Cajsa Greco, Eugenio Pedretti, Roberto Abreu, Ana Ambrosetti, Marco Braga, Simona Sarzi Bussotti, Maurizio Faggiano, Pompilio Takken, Tim Vigorito, Carlo Schwaab, Bernhard Coninx, Karin
A terceira mão : o gesto informe
The experience of the disabled body is the focus of this dissertation. The Third Hand is the subjective organism that stitches together the fragments of personal memory, artistic practice, and conceptual references. Between the efficiency and the deficiency of the body, the similarity and dissimilarity between the hands, there is the formless gesture in dialogue with Georges Bataille that is manifested through the drawing. His daily practice, inside and outside the studio, is the guiding thread of the confrontations between the hand and the instrument, between the hand and the world, in intimate research that reveals the symptoms behind the disabled corporeality, what I call decorporeity. Left hand and right hand in constant clashes in the capture of their gestural intentions, which from the drawing, unfold in performances, installations, and videos. The dissertation is built in three chapters that gradually lead to the approaches and findings of the study in intersection with works that subvert the function and symbology of the hands and with artists with disabilities who question the normative imaginary from their identities. Each chapter is composed of three subchapters that intertwine, with the series of drawings O Monstruário being the backbone that sustains the deviations of the body under investigation
2025-10-28T12:24:20Z
Souza, Daniel Moraes Siqueira
Alterations on peripheral blood B-cell subpopulations in very early arthritis patients
Objective. To characterize circulating B-cell subpopulations of arthritis patients with <6 weeks of disease duration. Methods. Peripheral blood samples were collected from very early untreated polyarthritis patients, with <6 weeks of disease duration, for flow cytometric evaluation of B-cell subpopulations. Samples from patients who were later diagnosed as RA [very early RA (VERA)] were also collected 4–6 weeks after starting a low dose of prednisone (5–10 mg) and 4 months after reaching the minimum effective dose of MTX. A matched healthy group was used as a control. Results. VERA patients have a lower percentage of total peripheral blood memory B cells (CD19+CD27+) and a significant decrease in the frequency of circulating pre-switch memory B cells (CD19+IgD+CD27+) as compared with controls. Therapy with corticosteroids or MTX was unable to restore the normal frequencies of these B-cell subpopulations. A significant decrease in peripheral pre-switch memory B cells is equally observed in other early arthritis patients. Furthermore, no significant differences are found in the frequencies of CD4+ and CD8+ T cells in all patient groups. Conclusions. In very early polyarthritis patients, there is a reduction in circulating pre-switch memory B cells. The reasons that may account for this effect are still unknown. Short-term corticosteroids and MTX do not seem to have a direct effect on circulating B-cell subpopulations in VERA patients.
2025-10-28T12:14:55Z
Moura, Rita A. Weinmann, Pamela Pereira, Patrícia A. Caetano-Lopes, Joana Canhao, Helena Sousa, Elsa Mourão, Ana F. Rodrigues, Ana M. Queiroz, Mário V. Souto-Carneiro, Maria M. Graca, Luis Fonseca, João Eurico
Marcel Proust em busca da arte
«Les beaux livres sont écrits dans une sorte de langue étrangère»: assim Marcel Proust conclui o Contre Sainte-Beuve. Se ele se lançou na aventura de La Recherche, foi para tentar reencontrar a língua «perdida» do seu eu antigo, que apenas podia ser alcançada ao ser traduzida para essa “língua estrangeira” que é sempre a arte. É o que se tenta comprovar pelos ensaios críticos elegidos muito especialmente para esta antologia, pela sua originalidade e acuidade na leitura da obra proustiana.
2025-10-28T12:10:34Z
Negro, Francesca Basílio, Kelly
Editorial: Edible wild plants and fungi - resource to explore, preserve, and valuate
No summary/description provided
2025-10-28T12:23:14Z
Catarino, Luis Barros, Lillian Romeiras, Maria M.
Ethnomycological prospect of wild edible and medicinal mushrooms from Central and Southern Africa—A review
In several regions of Africa, the daily diet is partly dependent on the edible products from wild animals, plants, and mushrooms, driven by their availability, wide distribution in the local environment, and the low incomes of the general population. The documentation of ethnomycological information is particularly important to validate or correct the identification of specimens and the preservation of these natural resources with cultivation potential, thus improving their consumption and utilization for medicinal purposes. The number of wild edible mushroom species consumed varies between different regions of Africa, with around 300 species being documented in the literature. However, despite its rich biodiversity, the African continent is still underexploited, which is reflected in poor food contribution to populations that are often in need. Here, the safe use of mushrooms is guided by the insufficiency of studies that validate their nutritional and medicinal properties, since they are key factors in the suppression of protein deficiency in the everyday diet of the populations and a source of bioactive compounds useful for the formulation of added-value functional products. Thus, it becomes essential to investigate African mushrooms, not only from the identification point of view, but also in terms of nutritional, chemical, and bioactive characterization, hence deepen the knowledge about this valuable natural resource. Bearing these in mind, the main objective of this study is to systematize the knowledge available in scientific publications and specialized websites, thus gathering information about the valuable profits that come from using these widely appreciated natural products.
2025-10-28T12:29:40Z
Bastos, Claudete Liberal, Ângela Moldão, Margarida Catarino, Luís Barros, Lillian
Biota of coastal wetlands of Praia da Vitória (Terceira Island, Azores): Part 2 - Bryophytes
Background During the LIFE-CWR project "Ecological Restoration and Conservation of Praia da Vitória Coastal Wet Green Infrastructures", there was the opportunity to undertake a systematic record of bryophytes at Paul da Praia da Vitória (PPV), Paul do Belo Jardim (PBJ) and Paul da Pedreira do Cabo da Praia (PPCP), three coastal wetland areas of Praia da Vitória (Terceira, Azores, Portugal). The objective of the study was to perform a biodiversity assessment, comparing the three sites at two different moments, before and after the implementation of several conservation measures. This project also contributed to improve the knowledge of Azorean bryophyte diversity at both local and regional scales, including the recording of two new taxa for the Azores and three new taxa for Terceira Island. New information This paper reports the results of the first extensive survey of bryophyes of the three coastal wetland areas of Praia da Vitória (Terceira Island, Azores, Portugal). The identification of a total of 504 samples, 240 collected in 2013 and 2016 (before the LIFE-CWR intervention) and 265 in 2017 and 2018 (after the intervention), resulted in a list of 58 species of bryophytes (one hornwort, eight liverworts and 48 mosses). These include two new records for the Azores (Bryum klinggraeffii, Ptychostomum bornholmense), three new records for Terceira Island (Bryum tenuisetum, Dicranella howei, Trichostomum crispulum) and at least 15 new records for the municipality of Praia da Vitória (e.g., Cephaloziella hampeana). Some species that had not been recorded on the island since 1937 (e.g., Fissidens crispus) were collected during this study, as well as a Macaronesian endemic liverwort (Radula wichurae), an Iberian-Macaronesian liverwort (Frullania azorica) and a moss species with European distribution (Ptychomitrium nigrescens). From the recorded species, only one moss (Leptophascum leptophyllum), of subtropical origin, is considered invasive in Europe.
2025-10-28T12:11:58Z
Gabriel, Rosalina Pimentel, César Claro, David Brito, Mariana Díaz-Castillo, Javier Sérgio, Cecília Sim-Sim, Manuela Borges, Paulo
BioTIME: A database of biodiversity time series for the Anthropocene
Motivation The BioTIME database contains raw data on species identities and abundances in ecological assemblages through time. These data enable users to calculate temporal trends in biodiversity within and amongst assemblages using a broad range of metrics. BioTIME is being developed as a community-led open-source database of biodiversity time series. Our goal is to accelerate and facilitate quantitative analysis of temporal patterns of biodiversity in the Anthropocene. Main types of variables included The database contains 8,777,413 species abundance records, from assemblages consistently sampled for a minimum of 2 years, which need not necessarily be consecutive. In addition, the database contains metadata relating to sampling methodology and contextual information about each record. Spatial location and grain BioTIME is a global database of 547,161 unique sampling locations spanning the marine, freshwater and terrestrial realms. Grain size varies across datasets from 0.0000000158 km2 (158 cm2) to 100 km2 (1,000,000,000,000 cm2). Time period and grain BioTIME records span from 1874 to 2016. The minimal temporal grain across all datasets in BioTIME is a year. Major taxa and level of measurement BioTIME includes data from 44,440 species across the plant and animal kingdoms, ranging from plants, plankton and terrestrial invertebrates to small and large vertebrates. Software format .csv and .SQL.
2025-10-28T12:18:55Z
Dornelas, Maria Antão, Laura H. Moyes, Faye Bates, Amanda E. Magurran, Anne E. Adam, Dušan Akhmetzhanova, Asem A. Appeltans, Ward Arcos, José Manuel Arnold, Haley Ayyappan, Narayanan Badihi, Gal Baird, Andrew H. Barbosa, Miguel Barreto, Tiago Egydio Bässler, Claus Bellgrove, Alecia Belmaker, Jonathan Benedetti‐Cecchi, Lisandro Bett, Brian J. Bjorkman, Anne D. Błażewicz, Magdalena Blowes, Shane A. Bloch, Christopher P. Bonebrake, Timothy C. Boyd, Susan Bradford, Matt Brooks, Andrew J. Brown, James H. Bruelheide, Helge Budy, Phaedra Carvalho, Fernando Castañeda‐Moya, Edward Chen, Chaolun Allen Chamblee, John F. Chase, Tory J. Siegwart Collier, Laura Collinge, Sharon K. Condit, Richard Cooper, Elisabeth J. Cornelissen, J. Hans C. Cotano, Unai Kyle Crow, Shannan Damasceno, Gabriella Davies, Claire H. Davis, Robert A. Day, Frank P. Degraer, Steven Doherty, Tim S. Dunn, Timothy E. Durigan, Giselda Duffy, J. Emmett Edelist, Dor Edgar, Graham J. Elahi, Robin Elmendorf, Sarah C. Enemar, Anders Ernest, S. K. Morgan Escribano, Rubén Estiarte, Marc Evans, Brian S. Fan, Tung‐Yung Turini Farah, Fabiano Loureiro Fernandes, Luiz Farneda, Fábio Z. Fidelis, Alessandra Fitt, Robert Fosaa, Anna Maria Daher Correa Franco, Geraldo Antonio Frank, Grace E. Fraser, William R. García, Hernando Cazzolla Gatti, Roberto Givan, Or Gorgone‐Barbosa, Elizabeth Gould, William A. Gries, Corinna Grossman, Gary D. Gutierréz, Julio R. Hale, Stephen Harmon, Mark E. Harte, John Haskins, Gary Henshaw, Donald L. Hermanutz, Luise Hidalgo, Pamela Higuchi, Pedro Hoey, Andrew Van Hoey, Gert Hofgaard, Annika Holeck, Kristen Hollister, Robert D. Holmes, Richard Hoogenboom, Mia Hsieh, Chih‐hao Hubbell, Stephen P. Huettmann, Falk Huffard, Christine L. Hurlbert, Allen H. Macedo Ivanauskas, Natália Janík, David Jandt, Ute Jażdżewska, Anna Johannessen, Tore Johnstone, Jill Jones, Julia Jones, Faith A. M. Kang, Jungwon Kartawijaya, Tasrif Keeley, Erin C. Kelt, Douglas A. Kinnear, Rebecca Klanderud, Kari Knutsen, Halvor Koenig, Christopher C. Kortz, Alessandra R. Král, Kamil Kuhnz, Linda A. Kuo, Chao‐Yang Kushner, David J. Laguionie‐Marchais, Claire Lancaster, Lesley T. Min Lee, Cheol Lefcheck, Jonathan S. Lévesque, Esther Lightfoot, David Lloret, Francisco Lloyd, John D. López-Baucells, Adrià Louzao, Maite Madin, Joshua S. Magnússon, Borgþór Malamud, Shahar Matthews, Iain McFarland, Kent P. McGill, Brian McKnight, Diane McLarney, William O. Meador, Jason Meserve, Peter L. Metcalfe, Daniel J. Meyer, Christoph F. J. Michelsen, Anders Milchakova, Nataliya Moens, Tom Moland, Even Moore, Jon Mathias Moreira, Carolina Müller, Jörg Murphy, Grace Myers‐Smith, Isla H. Myster, Randall W. Naumov, Andrew Neat, Francis Nelson, James A. Paul Nelson, Michael Newton, Stephen F. Norden, Natalia Oliver, Jeffrey C. Olsen, Esben M. Onipchenko, Vladimir G. Pabis, Krzysztof Pabst, Robert J. Paquette, Alain Pardede, Sinta Paterson, David M. Pélissier, Raphaël Peñuelas, Josep Pérez‐Matus, Alejandro Pizarro, Oscar Pomati, Francesco Post, Eric Prins, Herbert H. T. Priscu, John C. Provoost, Pieter Prudic, Kathleen L. Pulliainen, Erkki Ramesh, B. R. Mendivil Ramos, Olivia Rassweiler, Andrew Rebelo, Jose Eduardo Reed, Daniel C. Reich, Peter B. Remillard, Suzanne M. Richardson, Anthony J. Richardson, J. Paul van Rijn, Itai Rocha, Ricardo Rivera‐Monroy, Victor H. Rixen, Christian Robinson, Kevin P. Ribeiro Rodrigues, Ricardo de Cerqueira Rossa‐Feres, Denise Rudstam, Lars Ruhl, Henry Ruz, Catalina S. Sampaio, Erica M. Rybicki, Nancy Rypel, Andrew Sal, Sofia Salgado, Beatriz Santos, Flavio A. M. Savassi‐Coutinho, Ana Paula Scanga, Sara Schmidt, Jochen Schooley, Robert Setiawan, Fakhrizal Shao, Kwang‐Tsao Shaver, Gaius R. Sherman, Sally Sherry, Thomas W. Siciński, Jacek Sievers, Caya da Silva, Ana Carolina Rodrigues da Silva, Fernando Silveira, Fabio L. Slingsby, Jasper Smart, Tracey Snell, Sara J. Soudzilovskaia, Nadejda A. Souza, Gabriel B. G. Maluf Souza, Flaviana Castro Souza, Vinícius Stallings, Christopher D. Stanforth, Rowan Stanley, Emily H. Mauro Sterza, José Stevens, Maarten Stuart‐Smith, Rick Rondon Suarez, Yzel Supp, Sarah Yoshio Tamashiro, Jorge Tarigan, Sukmaraharja Thiede, Gary P. Thorn, Simon Tolvanen, Anne Teresa Zugliani Toniato, Maria Totland, Ørjan Twilley, Robert R. Vaitkus, Gediminas Valdivia, Nelson Vallejo, Martha Isabel Valone, Thomas J. Van Colen, Carl Vanaverbeke, Jan Venturoli, Fabio Verheye, Hans M. Vianna, Marcelo Vieira, Rui P. Vrška, Tomáš Quang Vu, Con Van Vu, Lien Waide, Robert B. Waldock, Conor Watts, Dave Webb, Sara Wesołowski, Tomasz White, Ethan P. Widdicombe, Claire E. Wilgers, Dustin Williams, Richard Williams, Stefan B. Williamson, Mark Willig, Michael R. Willis, Trevor J. Wipf, Sonja Woods, Kerry D. Woehler, Eric J. Zawada, Kyle Zettler, Michael L.
Ensino das ciências numa perspetiva sociológica. Reflexões sobre uma trajetória de investigação
O livro apresenta um trajeto de investigação educacional, centrado no ensino das ciências segundo uma perspetiva sociológica. Neste percurso, que teve início nos anos 70 do século passado, abrangendo um período de mais de 40 anos, tiveram especial relevo os estudos realizados no âmbito do Grupo ESSA (Estudos Sociológicos da Sala de Aula). Para além da apresentação do trajeto e do respetivo comentário, o livro inclui a seleção de seis publicações sobre as quatro principais áreas de estudo que nortearam a investigação em que a autora participou, nomeadamente a interação família-escola, a formação de professores, a análise curricular e a prática pedagógica da escola. Destaca-se a publicação de um estudo que evidencia, numa perspetiva curricular, a crucial importância atribuída ao nível de exigência conceptual na educação em ciências.
Trends in High Nature Value farmland and ecosystem services valuation: a bibliometric review
High Nature Value farmland (HNVf) represents a rural landscape characterized by extensive farming practices. These lands not only deliver vital ecosystem services (ES) but also serve as significant harbors of biodiversity, underscoring their critical conservation status. Consequently, European Union countries have prioritized the identification, monitoring, and enhancement of HNVf systems in their policies. As governments and international organizations increasingly lean on green subsidies to promote sustainable environmental practices, the valuation of ecosystem services (VES) emerges as a crucial tool. This valuation offers both an economic rationale for conservation and aids in determining the optimal allocation of these subsidies for maximum environmental and economic return on investment. Given the potential for such valuations to shape and justify conservation subsidies, there is a growing imperative to understand the research trends and knowledge gaps in this realm. This article, through a bibliometric review, seeks to illuminate the size, growth trajectory, and thematic tendencies within HNVf and VES literature. Bibliometric analysis is recognized as promising in identifying research trends; thus, this article consists of a bibliometric review of HNVf and VES research. The objective is to identify the size, growth trajectory, and geographic distribution of HNVf and VES literature between the first publication until 2022, while assessing the critical publishing journals, authors, documents, and conceptual structure of the research fields (e.g., economic, social, and environmental). The analysis revealed a predominant concentration of research on HNVf in Europe, with limited studies conducted outside this continent. The primary focus of these studies revolved around subject areas such as environmental science, agriculture, and biological sciences. Conversely, regarding research on VES, there was no clear regional concentration. VES research publications mainly covered the interdisciplinary fields of economics, biology, and policymaking. As the fields of HNVf and VES have evolved, it is evident that there has been a stronger push towards data-driven approaches, emphasizing the need for tangible assessments and precise understanding. In examining the overlap between topics, the analysis revealed a gap between methodologies for HNVf monitoring and conservation and VES, highlighting the need for further development in crafting an integrated approach encompassing both areas.
2025-10-28T12:14:28Z
Girão, Inês Gomes, Eduardo Pereira, Paulo Rocha, Jorge
Solidarity typologies in dynamics between Portuguese emigrants and their parents
Motivations for migratory movements tend to be contextualised at an individual level and refer to opportunities related to the country of destination. In the Portuguese context, this view is increasingly limited when we analyse the emigration of young adults since this process directly involves family figures in the country of origin, as they tend to be the first source of support. This paper aims to explore the dimensions of intergenerational solidarity, analysing conflict as transversal dimension and the presence of ambivalence, for a proposal of behaviour typologies in Portuguese transnational families. Using a qualitative approach, young Portuguese adults who emigrated in the European space and Schengen area (N = 22) were interviewed addressing questions about their migratory projects, as well as their dynamics with their parents in Portugal. A thematic analysis was carried out with the support of the NVivo software. The results indicate four behaviour typologies: (1) high cohesion and dependence, (2) full solidarity tested with resilience, (3) affective and functional solidarities, with normative and value divergences, and (4) no solidarity and irreconcilable differences. The findings suggest the impact of intergenerational norms and values, as they may be at the origin of communicational patterns that increase well-being and resilience in migration projects.
2025-10-28T12:14:15Z
Barros, Carlos McGarrigle, Jennifer Santos, Ana Sofia Albert, Isabelle Murdock, Elke
«An infinitely growing pact with oneself»: Novalis on the origin of philosophy
The present article seeks to inquire the nature of Novalis’ difficult relation with philosophy. By founding this relation in a primordial spiritual conflict, wherein philosophy is the cause and the solution for the latter, as well as in an inescapable mythical understanding, wherein philosophy is at the same time necessary, and yet necessarily expendable, we intend to prove Novalis’ own seemingly contradictory, yet infinitely productive concept of philosophizing: one where philosophizing is a ductile, organic way of dealing with the problem between the human being and the absolute. Furthermore, we wish to prove how this is most visibly considered in the sub-problem of the origin of philosophy, which sets the tone for Novalis’ remaining philosophical edifice and inscribes him as one of the leading opposers of a systematic philosophy — and hence, as an advocator of the impossibility of attaining the absolute through philosophy.
Expectativas e experiências : territórios do design contemporâneo em Portugal : promessas, resultados
No summary/description provided