Global RCAAP Repository | PISTA Digital

Henri Poincaré, ciência e materialismo: o papel das hipóteses na oscilação entre atomismo e continuísmo

No summary/description provided

2025-10-28T12:14:42Z

http://hdl.handle.net/10451/60094

Philot, André Carli Videira, António A. P.

Jeremy Gray, Henri Poincaré, A scientific biography, 2013

No summary/description provided

2025-10-28T12:25:54Z

http://hdl.handle.net/10451/60095

Paz, María de

Othering the woman in Augustan Rome: Sophoniba's exemplum

Este estudo centra-se na construção da figura da princesa Sofoniba, de Cartago, e no modo como ela serve de paradigma para a construção da alteridade feminina na cultura romana do tempo de Augusto.

2025-10-28T12:27:13Z

http://hdl.handle.net/10451/60096

Rodrigues, Nuno Simões

Aging disrupts MANF-mediated immune modulation during skeletal muscle regeneration

Age-related decline in skeletal muscle regenerative capacity is multifactorial, yet the contribution of immune dysfunction to regenerative failure is unknown. Macrophages are essential for effective debris clearance and muscle stem cell activity during muscle regeneration, but the regulatory mechanisms governing macrophage function during muscle repair are largely unexplored. Here, we uncover a new mechanism of immune modulation operating during skeletal muscle regeneration that is disrupted in aged animals and relies on the regulation of macrophage function. The immune modulator mesencephalic astrocyte-derived neurotrophic factor (MANF) is induced following muscle injury in young mice but not in aged animals, and its expression is essential for regenerative success. Regenerative impairments in aged muscle are associated with defects in the repair-associated myeloid response similar to those found in MANF-deficient models and could be improved through MANF delivery. We propose that restoring MANF levels is a viable strategy to improve myeloid response and regenerative capacity in aged muscle.

2025-10-28T12:15:10Z

http://hdl.handle.net/10451/60097

Sousa, Neuza S. Brás, Margarida F. Antunes, Inês Lindholm, Päivi Mendes Neves, Joana Sousa-Victor, Pedro

Transcatheter interventions for left-sided valvular heart disease complicated by cardiogenic shock: a consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) in collaboration with the Association for Acute Cardiovascular Care (ACVC) and the ESC Working Group on Cardiovascular Surgery

Valvular heart disease (VHD) is one of the most frequent causes of heart failure (HF) and is associated with poor prognosis, particularly among patients with conservative management. The development and improvement of catheter-based VHD interventions have broadened the indications for transcatheter valve interventions from inoperable/high-risk patients to younger/lower-risk patients. Cardiogenic shock (CS) associated with severe VHD is a clinical condition with a very high risk of mortality for which surgical treatment is often deemed a prohibitive risk. Transcatheter valve interventions might be a promising alternative in this setting given that they are less invasive. However, supportive scientific evidence is scarce and often limited to small case series. Current guidelines on VHD do not contain specific recommendations on how to manage patients with both VHD and CS. The purpose of this clinical consensus statement, developed by a group of international experts invited by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) Scientific Documents and Initiatives Committee, is to perform a review of the available scientific evidence on the management of CS associated with left-sided VHD and to provide a rationale and practical approach for the application of transcatheter valve interventions in this specific clinical setting.

2025-10-28T12:21:01Z

http://hdl.handle.net/10451/60098

Fraccaro, Chiara Karam, Nicole Möllmann, Helge Bleiziffer, Sabine Bonaros, Nikolaos Teles, Rui Campante Carrilho-Ferreira, Pedro Chieffo, Alaide Czerny, Martin Donal, Erwan Dudek, Dariusz Dumonteil, Nicolas Esposito, Giovanni Fournier, Stephane Hassager, Christian Kim, Won-Keun Krychtiuk, Konstantin A. Mehilli, Julinda Pręgowski, Jerzy Stefanini, Giulio G. Ternacle, Julien Thiele, Holger Thielmann, Matthias Vincent, Flavien von Bardeleben, Ralph Stephan Tarantini, Giuseppe