RCAAP Repository
A responsabilidade ambiental por actos de direito internacional público
No summary/description provided
O sigilo fiscal
No summary/description provided
Sobre o regime da alteração substancial de factos, na fase de julgamento, em processo-crime
No summary/description provided
Anglicismos em textos jurídicos portugueses
No summary/description provided
2025-10-28T12:13:33Z
Nunes, Helena Margarida Pires de Sousa
Política e direito
No summary/description provided
O acesso à jurisdição no espaço integrado do Mercosul
No summary/description provided
2025-10-28T12:13:20Z
Caminha, Maria do Carmo Puccini
A função do Senado no controle difuso de constitucionalidade no Brasil
No summary/description provided
Da "auctoritas" como elemento constitutivo da juridicidade
No summary/description provided
2025-10-28T12:29:40Z
Gonçalves, Diogo Costa, 1980-
A iniciativa legislativa popular
No summary/description provided
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis
Objective. CD8+ T cells are part of the T cell pool infiltrating the synovium in rheumatoid arthritis (RA). However, their role in the pathogenesis of RA has not been fully delineated. Using the K/BxN mouse model of spontaneous chronic arthritis, which shares many similarities with RA, we studied the potential of CD8 T cell depletion with monoclonal antibodies (mAb) to stop and reverse the progression of experimental arthritis. Methods. CD8+ T cells from the blood and articular infiltrate of K/BxN mice were characterized for cell surface phenotypic markers and for cytokine production. Additionally, mice were treated with specific anti-CD8 mAb (YTS105 and YTS169.4), with and without thymectomy. Results. CD8+ T cells from the peripheral blood and joints of K/BxN mice were mainly CD69+ and CD62L-CD27+ T cells expressing proinflammatory cytokines (interferon-γ [IFNγ], tumor necrosis factor α [TNFα], interleukin-17a [IL-17A], and IL-4), and granzyme B. In mice receiving anti-CD8 mAb, the arthritis score improved 5 days after treatment. Recovery of the CD8+ T cells was associated with a new increase in the arthritis score after 20 days. In thymectomized and anti-CD8 Ab–treated mice, the arthritis score improved permanently. Histologic analysis showed an absence of inflammatory infiltrate in the anti-CD8 mAb–treated mice. In anti-CD8 mAb–treated mice, the serologic levels of TNFα, IFNγ, IL-6, and IL-5 normalized. The levels of the disease-related anti–glucose-6-phosphate isomerase antibodies did not change. Conclusion. These results indicate that synovial activated effector CD8 T cells locally synthesize proinflammatory cytokines (IFNγ, TNFα, IL-17, IL-6) and granzyme B in the arthritic joint, thus playing a pivotal role in maintaining chronic synovitis in the K/BxN mouse model of arthritis.
2025-10-28T12:22:21Z
Raposo, Bruno R. Rodrigues-Santos, Paulo Carvalheiro, Helena Água-Doce, Ana M. Carvalho, Lina Pereira da Silva, José A. Graça, Luís Souto-Carneiro, M. Margarida
Acórdão da relação de Lisboa de 5 de Fevereiro de 2002
No summary/description provided
2025-10-28T12:26:21Z
Rei, Maria Raquel Aleixo Antunes, 1969-
O regime jurídico-legal do Instituto Hidrográfico como laboratório de Estado
No summary/description provided
2025-10-28T12:28:46Z
Pinto, Eduardo Vera-Cruz, 1961-
Para reforma do direito penal e disciplinar da marinha mercante
No summary/description provided
2025-10-28T12:22:48Z
Almeida, Luís Duarte de Lamego, António Reis, Sónia Maria Moreira
A convenção sobre os direitos da criança
No summary/description provided
Lectio brevissima
No summary/description provided
2025-10-28T12:21:14Z
Villela, João Baptista, 1937-
Apreciação do relatório sobre o programa, os conteúdos e os métodos do ensino de uma disciplina de direito constitucional (justiça constitucional) para um curso de mestrado, apresentado pelo Doutor Fernando Alves Correia em provas de agregação
No summary/description provided
Programa de direito das obrigações
No summary/description provided
Karl Galinsky, Augustan Culture. An interpretative introduction, Princeton-New Jersey, Princeton University Press, 1996, 474 pp.
No summary/description provided
2025-10-28T12:12:26Z
Pinto, Eduardo Vera-Cruz, 1961-
A reserva da intimidade da vida privada familiar
No summary/description provided
2025-10-28T12:10:18Z
Ascensão, José de Oliveira, 1932-2022
La justicia administrativa en el cambio de siglo
No summary/description provided
2025-10-28T12:11:44Z
García de Enterría, Eduardo, 1923-